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Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory siteStructure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasisCrystal Structure of a Putative Methyltransferase from Mycobacterium tuberculosis: Misannotation of a Genome Clarified by Protein Structural AnalysisThe anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variantsPreventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfoldingRational design of an organometallic glutathione transferase inhibitorInfluence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: Structure-thermodynamic relationships and thermal stabilityThiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human RhinovirusStructural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent CytolysinsSolution structure and peptide binding of the SH3 domain from human FynAn intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin.The folding kinetics and thermodynamics of the Fyn-SH3 domain.The biological function of an insect antifreeze protein simulated by molecular dynamicsStructures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysinsCopper binding to the Alzheimer's disease amyloid precursor proteinAnxiety over GABA(A) receptor structure relieved by AChBP.Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.Mechanism of activation of protein kinase JAK2 by the growth hormone receptor.From glutathione transferase to pore in a CLIC.Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.Molecular evolution of glutathione S-transferases in the genus Drosophila.Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites.Oncogenic protein interfaces: small molecules, big challenges.Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase.Design of a conformationally defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor.Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase.Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility.Insights into the structural basis for zinc inhibition of the glycine receptor.Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: identification of BTA9881 as a preclinical candidate.The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1.Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents.Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1.The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster.Electrostatic and hydrophobic forces tether the proximal region of the angiotensin II receptor (AT1A) carboxyl terminus to anionic lipids.Solid-state NMR conformational studies of a melittin-inhibitor complex.
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
@nl
հետազոտող
@hy
name
Craig J Morton
@ast
Craig J Morton
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Craig J Morton
@es
Craig J Morton
@nl
Craig J Morton
@sl
type
label
Craig J Morton
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Craig J Morton
@en
Craig J Morton
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Craig J Morton
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Craig J Morton
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altLabel
Craig Morton
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prefLabel
Craig J Morton
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Craig J Morton
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Craig J Morton
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Craig J Morton
@nl
Craig J Morton
@sl
P106
P21
P31
P4012
P496
0000-0001-5452-5193