about
ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replicationIn the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase.Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and functionA unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNAGenetic organization of the Vibrio harveyi DnaA gene region and analysis of the function of the V. harveyi DnaA protein in Escherichia coliCdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopyCdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.Exceeding the limits - Cdc45 overexpression turns bad.The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae.Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.Helicase loading: how to build a MCM2-7 double-hexamer.Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated.The GTP-dependent restriction enzyme McrBC from Escherichia coli forms high-molecular mass complexes with DNA and produces a cleavage pattern with a characteristic 10-base pair repeat.ATP- and ADP-dnaA protein, a molecular switch in gene regulation.From structure to mechanism-understanding initiation of DNA replication.From footprint to toeprint: a close-up of the DnaA box, the binding site for the bacterial initiator protein DnaA.Recognition of DNA by omega protein from the broad-host range Streptococcus pyogenes plasmid pSM19035: analysis of binding to operator DNA with one to four heptad repeats.Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formationThe ORC/Cdc6/MCM2–7 complex, a new power player for regulated helicase loadingSeeing is believing: the MCM2-7 helicase trapped in complex with its DNA loader.A top-down view on DNA replication and recombination from 9,000 feet above sea level.Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.Identification of the chromosomal replication origin from Thermus thermophilus and its interaction with the replication initiator DnaA.Functional domains of DnaA proteins.The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression.The Escherichia coli SeqA protein binds specifically and co-operatively to two sites in hemimethylated and fully methylated oriCReplicating repetitive DNA
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Christian Speck
@ast
Christian Speck
@en
Christian Speck
@es
Christian Speck
@nl
Christian Speck
@sl
type
label
Christian Speck
@ast
Christian Speck
@en
Christian Speck
@es
Christian Speck
@nl
Christian Speck
@sl
prefLabel
Christian Speck
@ast
Christian Speck
@en
Christian Speck
@es
Christian Speck
@nl
Christian Speck
@sl
P1053
G-2882-2011
P106
P1153
7003432500
P21
P31
P3829
P496
0000-0001-6646-1692