In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.
about
A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase.Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and functionA unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNAProtein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiationDynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle.Juvenile Hormone Activates the Transcription of Cell-division-cycle 6 (Cdc6) for Polyploidy-dependent Insect Vitellogenesis and OogenesisCryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.Chromosome Duplication in Saccharomyces cerevisiae.Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated.Mechanisms and regulation of DNA replication initiation in eukaryotes.Mechanisms for initiating cellular DNA replication.From structure to mechanism-understanding initiation of DNA replication.Mechanism of Archaeal MCM Helicase Recruitment to DNA Replication Origins.Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines.Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase.The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formationMultiple functions for Mcm2-7 ATPase motifs during replication initiationThe ORC/Cdc6/MCM2–7 complex, a new power player for regulated helicase loadingCryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.Prereplication-complex formation: a molecular double take?
P2860
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P2860
In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
In the absence of ATPase activ ...... o MCM2-7 hexamer dimerization.
@ast
In the absence of ATPase activ ...... o MCM2-7 hexamer dimerization.
@en
In the absence of ATPase activ ...... o MCM2-7 hexamer dimerization.
@nl
type
label
In the absence of ATPase activ ...... o MCM2-7 hexamer dimerization.
@ast
In the absence of ATPase activ ...... o MCM2-7 hexamer dimerization.
@en
In the absence of ATPase activ ...... o MCM2-7 hexamer dimerization.
@nl
prefLabel
In the absence of ATPase activ ...... o MCM2-7 hexamer dimerization.
@ast
In the absence of ATPase activ ...... o MCM2-7 hexamer dimerization.
@en
In the absence of ATPase activ ...... o MCM2-7 hexamer dimerization.
@nl
P2093
P2860
P356
P1476
In the absence of ATPase activ ...... to MCM2-7 hexamer dimerization
@en
P2093
Alberto Riera
Cecile Evrin
Juergen Zech
M Carmen Herrera
Pippa Clarke
Shlomo Brill
P2860
P304
P356
10.1093/NAR/GKT043
P407
P577
2013-02-01T00:00:00Z