about
Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesisIs there a risk of zoonotic disease due to adenoviruses?Mechanisms of cancer cell killing by the adenovirus E4orf4 proteinLocalization and importance of the adenovirus E4orf4 protein during lytic infectionIn vitro and in vivo biology of recombinant adenovirus vectors with E1, E1/E2A, or E1/E4 deleted.The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.Adenovirus late gene expression does not require a Rev-like nuclear RNA export pathway.Regulation of adenovirus-mediated transgene expression by the viral E4 gene products: requirement for E4 ORF3.Overexpression of cyclin A inhibits augmentation of recombinant adeno-associated virus transduction by the adenovirus E4orf6 protein.The role of adenovirus E4orf4 protein in viral replication and cell killing.Nuclear domain 10, the site of DNA virus transcription and replication.Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit.Human adenovirus type 9 E4 open reading frame 1 encodes a cytoplasmic transforming protein capable of increasing the oncogenicity of CREF cellsAdenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosisAdenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells.Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen-activated protein kinase regulates expression of early region 4Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.A carboxy-terminal region required by the adenovirus type 9 E4 ORF1 oncoprotein for transformation mediates direct binding to cellular polypeptides.Differential activation of cellular DNA damage responses by replication-defective and replication-competent adenovirus mutantsAdenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in ratsE4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirusAdenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection.Replication but not transcription of simian virus 40 DNA is dependent on nuclear domain 10.Minimal cis-acting elements required for adenovirus genome packaging.Effect of the E4 region on the persistence of transgene expression from adenovirus vectors.Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenoviruses.Construction of an adenovirus type 7a E1A- vector.Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation.The adenovirus E4 ORF3 protein binds and reorganizes the TRIM family member transcriptional intermediary factor 1 alpha.The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection.The adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes.Amino acid exchanges in the putative nuclear export signal of adenovirus type 5 L4-100K severely reduce viral progeny due to effects on hexon biogenesis.Reduced toxicity, attenuated immunogenicity and efficient mediation of human p53 gene expression in vivo by an adenovirus vector with deleted E1-E3 and inactivated E4 by GAL4-TATA promoter replacement.
P2860
Q24684374-531EB56B-4CCE-4EFB-BCC6-5FC198C461ABQ28080712-4A10FE32-D412-47ED-BBB8-2340E331E8CBQ28081729-371C8FAA-022F-4312-A4CF-6173C7FE1F00Q30486046-9F3D12E1-7C8F-438F-9F4B-C3016839CA5DQ33782356-AF1CB325-37EE-4441-A139-BF8EC6E8930DQ33783779-F8DC9EAB-4EB8-4BCC-8D35-F554BA1F595EQ33808331-E32044CD-E6DF-4252-915C-2E7F6BA15C71Q33819873-802D8D36-DEB2-43AF-80FE-A7F24750D362Q33824969-5449B674-12B4-413A-A33F-DD0D842D5632Q34468774-223CCF51-85DF-4A9B-8FCB-324712BFE55DQ34476075-1A6A2279-6EDC-4475-B54A-5DF3376FBE72Q35853884-1E368CEB-11C3-4FB9-A1A2-900CE75E6E1BQ35854433-3FE0A20C-7DFE-4FB5-9F0A-9BB96D48B3B6Q35868343-2E2E9D56-D84F-4E68-BCB7-133482FE3D69Q35868511-37071F34-CCA6-4509-974F-4FA11F0EC7CEQ35882622-367DD5E2-E090-48CC-AB79-7D7C2393349BQ35883364-EA4FF71B-F568-45BB-B64F-4DC161CF3BBDQ35896138-4CD29713-6C6D-498B-B33B-A44FE1069F6DQ36414398-B62B1B27-930E-4394-830D-559B85E45AF7Q36634353-92C6066E-3B0E-43CE-B68E-2899776ED3B2Q37110666-528DE18D-EDE2-46F6-A269-2A68D3315AB3Q39421013-6EB6D4FB-59D5-461E-A372-B5CF5C1B56C4Q39593421-C6B2434E-F9B1-4BAD-813F-072AFA1971BDQ39748690-D83081A9-5B37-4544-84B4-B2D85F5DCFB7Q39878778-6740B108-777F-4D3E-9FBF-4616212C6EB5Q39879953-071035AA-F639-46E1-A485-9335B2F34B8BQ39882405-5C6AD3D9-318F-42C8-9029-59ABC17A3B70Q40140948-AEBBB514-5C5B-463C-958E-FB274A4E9519Q40173431-D84F17FE-9599-4AA4-B049-C91E4F99FFC5Q42583162-BCC7A4F3-BAF7-4E81-B12B-8FE30EACA0ADQ42872522-A04AB94F-650D-4F6E-9E35-A6EA6DDFEB71Q42962086-62C49E75-E616-4EF6-9A0A-C00E451DEBBCQ45859680-27B2E5EE-AB2A-40E4-947E-69B588BF60ED
P2860
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Adenovirus early region 4 and viral DNA synthesis.
@en
Adenovirus early region 4 and viral DNA synthesis.
@nl
type
label
Adenovirus early region 4 and viral DNA synthesis.
@en
Adenovirus early region 4 and viral DNA synthesis.
@nl
prefLabel
Adenovirus early region 4 and viral DNA synthesis.
@en
Adenovirus early region 4 and viral DNA synthesis.
@nl
P2093
P356
P1433
P1476
Adenovirus early region 4 and viral DNA synthesis.
@en
P2093
P304
P356
10.1006/VIRO.1993.1188
P407
P577
1993-04-01T00:00:00Z