Modular organization of genes required for complex polyketide biosynthesis.
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Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulumIdentification and characterization of a gene cluster for synthesis of the polyketide antibiotic 2,4-diacetylphloroglucinol from Pseudomonas fluorescens Q2-87The biosynthetic gene cluster for the polyketide immunosuppressant rapamycinThe embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutolBiosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2)Cracking the polyketide codeSynthetic biology for pharmaceutical drug discoverySynthetic biology of antimicrobial discoveryCrystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channelStructural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B SynthaseSolution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthaseCyanobacterial Polyketide Synthase Docking Domains: A Tool for Engineering Natural Product BiosynthesisThe Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase componentNext-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungiIdentification of genes implicated in toxin production in the cyanobacterium Cylindrospermopsis raciborskiiEvolutionary implications of bacterial polyketide synthasesEvolution of polyketide synthases in bacteriaFunctional replacement of genes for individual polyketide synthase components in Streptomyces coelicolor A3(2) by heterologous genes from a different polyketide pathwayEfficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthaseGene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteriaInsights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical ProbesMultiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapesA multiplasmid approach to preparing large libraries of polyketides.Production of the tubulin destabilizer disorazol in Sorangium cellulosum: biosynthetic machinery and regulatory genes.Combinatorial biosynthesis--potential and problems.Microbial polyketide synthases: more and more prolific.Natural Products as a Foundation for Drug Discovery.Computational identification and analysis of orphan assembly-line polyketide synthases.Pseudomonas syringae phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetasesPlant metabolic clusters - from genetics to genomics.The methymycin/pikromycin pathway: a model for metabolic diversity in natural product biosynthesisNovel macrolides through genetic engineering.In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.Modulation of lipid metabolism and spiramycin biosynthesis in Streptomyces ambofaciens unstable mutants.Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.Polyketide synthase pathways identified from a metagenomic library are derived from soil Acidobacteria.Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C.
P2860
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P2860
Modular organization of genes required for complex polyketide biosynthesis.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Modular organization of genes required for complex polyketide biosynthesis.
@en
Modular organization of genes required for complex polyketide biosynthesis.
@nl
type
label
Modular organization of genes required for complex polyketide biosynthesis.
@en
Modular organization of genes required for complex polyketide biosynthesis.
@nl
prefLabel
Modular organization of genes required for complex polyketide biosynthesis.
@en
Modular organization of genes required for complex polyketide biosynthesis.
@nl
P2093
P356
P1433
P1476
Modular organization of genes required for complex polyketide biosynthesis.
@en
P2093
P304
P356
10.1126/SCIENCE.2024119
P407
P577
1991-05-01T00:00:00Z