Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria
about
The genome of Mycobacterium leprae: a minimal mycobacterial gene set.Interaction between polyketide synthase and transporter suggests coupled synthesis and export of virulence lipid in M. tuberculosis.Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis.Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosisRole of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameMycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiationDisruption of the genes encoding antigen 85A and antigen 85B of Mycobacterium tuberculosis H37Rv: effect on growth in culture and in macrophagesp-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosisPosttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expressionThe Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesisIdentification of the missing trans-acting enoyl reductase required for phthiocerol dimycocerosate and phenolglycolipid biosynthesis in Mycobacterium tuberculosisDisruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregationAttenuation of Mycobacterium tuberculosis by disruption of a mas-like gene or a chalcone synthase-like gene, which causes deficiency in dimycocerosyl phthiocerol synthesisMycobacterial polyketide-associated proteins are acyltransferases: proof of principle with Mycobacterium tuberculosis PapA5Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acidsOverexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosisIdentification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesisCharacterization of three glycosyltransferases involved in the biosynthesis of the phenolic glycolipid antigens from the Mycobacterium tuberculosis complexAttenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosisInactivation of polyketide synthase and related genes results in the loss of complex lipids in Mycobacterium tuberculosis H37RvAnalysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrierMolecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complexAn acyl-CoA synthetase in Mycobacterium tuberculosis involved in triacylglycerol accumulation during dormancyWidespread occurrence and genomic context of unusually small polyketide synthase genes in microbial consortia associated with marine spongesThe largest open reading frame (pks12) in the Mycobacterium tuberculosis genome is involved in pathogenesis and dimycocerosyl phthiocerol synthesis.A novel interaction linking the FAS-II and phthiocerol dimycocerosate (PDIM) biosynthetic pathways.Genomic Insight into Mechanisms of Reversion of Antibiotic Resistance in Multidrug Resistant Mycobacterium tuberculosis Induced by a Nanomolecular Iodine-Containing Complex FS-1.Identification of phthiodiolone ketoreductase, an enzyme required for production of mycobacterial diacyl phthiocerol virulence factorsComparative genomics of cell envelope components in mycobacteria.Mycobacterium tuberculosis pathogenesis and molecular determinants of virulenceMicrobial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems.Microbial gutta-percha degradation shares common steps with rubber degradation by Nocardia nova SH22a.Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids.Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum.Methylmalonyl coenzyme A selectivity of cloned and expressed acyltransferase and beta-ketoacyl synthase domains of mycocerosic acid synthase from Mycobacterium bovis BCG.Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling.Both phthiocerol dimycocerosates and phenolic glycolipids are required for virulence of Mycobacterium marinum.Whole-Genome Sequencing and Comparative Analysis of Mycobacterium brisbanense Reveals a Possible Soil Origin and Capability in Fertiliser SynthesisDifferential gene expression between Mycobacterium bovis and Mycobacterium tuberculosisGenomic epidemiology of Lineage 4 Mycobacterium tuberculosis subpopulations in New York City and New Jersey, 1999-2009.
P2860
Q24805934-4A3E4072-6938-4E00-BA67-0414CB57C0F3Q24817176-90A93946-CF69-4689-95A4-FFA4572B7858Q27687284-064E77D8-87A2-4AE9-9E15-CAA045919227Q28486206-999D0872-6C39-49D6-AD44-B5E313F11622Q28486209-33C7B2A4-8E6A-4FB9-B865-93E0AC0D185DQ28486211-E0D444C6-EB8B-4A13-A83C-4D1E991EE96AQ28486461-65B6751F-BB85-4EE6-A2B0-E9571B7717BFQ28486582-43AA9B40-FD94-4927-98A5-B794A685D073Q28486877-CDA07481-1719-4062-8E87-40C0DE222C4AQ28486880-9331A908-8CC6-4C30-B801-6340496C9026Q28486930-23E97834-B79C-4E1C-BBCA-091CA60FC6F6Q28487050-E6A723F7-3471-4BDA-B62A-553A77BB4E4AQ28487105-D9DD3821-CE48-45AC-B11D-5646C8646CD7Q28487230-3330168B-4F59-42FA-86A5-BBE6AAE75FDBQ28487265-9D1A56A5-1C3A-4FE8-9B64-5F0CECF34A22Q28487294-06475F61-F722-407D-9027-041EF99D368DQ28487304-C6422793-FEB3-4417-9397-B80F253BE0ADQ28487371-BFFC1888-704B-4DA9-A2D9-7E4FFDEC8F24Q28487409-CD9AF090-04C0-4A5C-B900-AE6DA8624D3BQ28487447-B37807BB-F7D3-4D17-BDFB-96C890F80614Q28487534-F0C9E5BD-E095-47B8-A91E-36EA859F0396Q28487542-3935B3FB-B5D2-4CB5-9D04-8828A31F7CDAQ28542621-E83E382C-A4F8-48CB-B3F8-2C29CF4EA460Q28762852-C5035DE0-574D-43AD-A881-C1B7E4B009D6Q31147222-7D0A19C8-CFA8-4F77-B0AE-C35E75A009BFQ33360202-A48BB425-8FFB-440E-AF88-7B201734DBF9Q33645712-8170563F-D9C3-4C23-99E2-02B8F08A1DCCQ33885721-88E16429-453C-4BE1-B072-D8DE6A7604B8Q33900542-2565951D-6544-4C7B-871B-C2184401B2CDQ34213787-3CD1F075-1465-411A-91F3-53CA134F8843Q34346455-D2CC75B9-C262-4A73-82DF-841375F4ED2DQ34503752-12C8A466-8936-4AC5-8827-80F3A09A79D7Q34628570-5BD88687-91E9-4E9F-B06C-63294B806C22Q35107277-E0653AE8-558D-4042-8CB1-894F5D83EC06Q35633821-0D6985AB-79FA-4302-BB44-4455723B0C4DQ35691083-BD8E9EBF-32C5-43C9-8800-AAEF2A188598Q35867580-C62C1E47-1D05-4884-84AF-9F31558F4578Q35975062-FD2F3A4F-BE27-4EFE-BE35-67BBEBA07B7DQ36148852-D286DD53-497B-41B7-87A0-0B3B0617C1B4Q36199999-1BB6EA18-E094-4E61-B335-1FF65A6C267F
P2860
Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria
description
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1997
@ast
im Juli 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/07/04)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/07/04)
@nl
наукова стаття, опублікована в липні 1997
@uk
name
Gene knockout reveals a novel ...... que to pathogenic mycobacteria
@ast
Gene knockout reveals a novel ...... que to pathogenic mycobacteria
@en
Gene knockout reveals a novel ...... que to pathogenic mycobacteria
@nl
type
label
Gene knockout reveals a novel ...... que to pathogenic mycobacteria
@ast
Gene knockout reveals a novel ...... que to pathogenic mycobacteria
@en
Gene knockout reveals a novel ...... que to pathogenic mycobacteria
@nl
prefLabel
Gene knockout reveals a novel ...... que to pathogenic mycobacteria
@ast
Gene knockout reveals a novel ...... que to pathogenic mycobacteria
@en
Gene knockout reveals a novel ...... que to pathogenic mycobacteria
@nl
P2093
P2860
P921
P3181
P356
P1476
Gene knockout reveals a novel ...... que to pathogenic mycobacteria
@en
P2093
A. K. Azad
N. D. Fernandes
P. E. Kolattukudy
T. D. Sirakova
P2860
P304
16741–16745
P3181
P356
10.1074/JBC.272.27.16741
P407
P577
1997-07-04T00:00:00Z