The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase.
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Haloalkaliphilic Streptomyces spp. AJ8 isolated from solar salt works and its' pharmacological potentialThe complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolitesFactor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domainsA polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetlesGenetics of zwittermicin a production by Bacillus cereusBiosynthesis and function of polyacetylenes and allied natural productsDeciphering tuberactinomycin biosynthesis: isolation, sequencing, and annotation of the viomycin biosynthetic gene clusterSTAS domain structure and functionRadical SAM-mediated methylation reactionsRadical-mediated enzymatic methylation: a tale of two SAMSAcyl-CoA hydrolysis by the high molecular weight protein 1 subunit of yersiniabactin synthetase: mutational evidence for a cascade of four acyl-enzyme intermediates during hydrolytic editingIdentification of Sare0718 as an alanine-activating adenylation domain in marine actinomycete Salinispora arenicola CNS-205Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomesIdentification of new, conserved, non-ribosomal peptide synthetases from fluorescent pseudomonads involved in the biosynthesis of the siderophore pyoverdineA hybrid NRPS-PKS gene cluster related to the bleomycin family of antitumor antibiotics in Alteromonas macleodii strainsPhylogenetic evidence for the early evolution of microcystin synthesisNatural-product sugar biosynthesis and enzymatic glycodiversification.Partial purification and identification of GDP-mannose 3",5"-epimerase of Arabidopsis thaliana, a key enzyme of the plant vitamin C pathwayStructural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42.Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner.In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites.The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892.Endophytic Actinobacteria Associated with Dracaena cochinchinensis Lour.: Isolation, Diversity, and Their Cytotoxic ActivitiesStreptomyces sp. MUM212 as a Source of Antioxidants with Radical Scavenging and Metal Chelating PropertiesIn vitro characterization of IroB, a pathogen-associated C-glycosyltransferase.Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo.Natural products version 2.0: connecting genes to molecules.A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis.The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversityNovel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin.Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase.Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin.Engineering polyketide synthases and nonribosomal peptide synthetases.Characterization of the lnmKLM genes unveiling key intermediates for β-alkylation in leinamycin biosynthesis.Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analogPolyketide and non-ribosomal peptide synthases: falling together by coming apart.
P2860
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P2860
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
The biosynthetic gene cluster ...... ses and a polyketide synthase.
@en
The biosynthetic gene cluster ...... ses and a polyketide synthase.
@nl
type
label
The biosynthetic gene cluster ...... ses and a polyketide synthase.
@en
The biosynthetic gene cluster ...... ses and a polyketide synthase.
@nl
prefLabel
The biosynthetic gene cluster ...... ses and a polyketide synthase.
@en
The biosynthetic gene cluster ...... ses and a polyketide synthase.
@nl
P2093
P1476
The biosynthetic gene cluster ...... ses and a polyketide synthase.
@en
P2093
P304
P356
10.1016/S1074-5521(00)00011-9
P577
2000-08-01T00:00:00Z