Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.
about
Structure and activity of the acid-sensing ion channelsASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filtersInteraction of the aromatics Tyr-72/Trp-288 in the interface of the extracellular and transmembrane domains is essential for proton gating of acid-sensing ion channelsA combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a.Ionization Properties of Histidine Residues in the Lipid Bilayer Membrane Environment.The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function.Does closure of acid-sensing ion channels reduce ischemia/reperfusion injury in the rat brain?Ionotropic and metabotropic proton-sensing receptors involved in airway inflammation in allergic asthmaIonotropic receptors and ion channels in ischemic neuronal death and dysfunction.Na+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleftA synaptic DEG/ENaC ion channel mediates learning in C. elegans by facilitating dopamine signalling.Insights into the mechanism of pore opening of acid-sensing ion channel 1a.Second transmembrane domain modulates epithelial sodium channel gating in response to shear stressAtomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels.Computational Tools for Interpreting Ion Channel pH-Dependence.Extracellular Subunit Interactions Control Transitions between Functional States of Acid-sensing Ion Channel 1a.ASIC3 channels in multimodal sensory perceptionHuman ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions.Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.Proton and non-proton activation of ASIC channels.Ion channels in renal disease.Gating transitions in the palm domain of ASIC1a.Exploration of the Peptide Recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel.Optogenetic approaches addressing extracellular modulation of neural excitability.Structural mechanisms underlying the function of epithelial sodium channel/acid-sensing ion channel.Potential cation and H+ binding sites in acid sensing ion channel-1.Extracellular protons regulate human ENaC by modulating Na+ self-inhibitionThe cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction.Two residues in the extracellular domain convert a nonfunctional ASIC1 into a proton-activated channelIndependent contribution of extracellular proton binding sites to ASIC1a activation.Diarylamidines: high potency inhibitors of acid-sensing ion channels.Insights into the molecular determinants of proton inhibition in an acid-inactivated degenerins and mammalian epithelial Na(+) channel.Protonation controls ASIC1a activity via coordinated movements in multiple domains.Identification of protein domains that control proton and calcium sensitivity of ASIC1a.Conformational changes associated with proton-dependent gating of ASIC1a.Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.Structural domains underlying the activation of acid-sensing ion channel 2a.ASICs and neuropeptides.A molecular mechanism for proton-dependent gating in KcsA.Capturing Functional Motions of Membrane Channels and Transporters with Molecular Dynamics Simulation.
P2860
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P2860
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.
@en
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.
@nl
type
label
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.
@en
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.
@nl
prefLabel
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.
@en
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.
@nl
P2093
P2860
P356
P1476
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.
@en
P2093
Georg Polleichtner
Hermann Schindelin
Martin Paukert
Xuanmao Chen
P2860
P304
P356
10.1074/JBC.M706811200
P407
P577
2007-11-01T00:00:00Z