Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma - Wikidata - wikimedia - TriplyDB

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

http://www.wikidata.org/entity/Q42636358

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The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling Raf family kinases: old dogs have learned new tricks MAPK pathway activation in pilocytic astrocytoma The molecular biology of WHO grade I astrocytomas Will kinase inhibitors make it as glioblastoma drugs?Pathological and molecular advances in pediatric low-grade astrocytoma Gamma Knife treatment of low-grade gliomas in children.Pediatric low-grade gliomas: how modern biology reshapes the clinical field.Diagnostic application of high resolution single nucleotide polymorphism array analysis for children with brain tumors The impact of coexisting genetic mutations on murine optic glioma biology.A pilot study using carboplatin, vincristine, and temozolomide in children with progressive/symptomatic low-grade glioma: a Children's Oncology Group study†Novel BRAF Alteration in a Sporadic Pilocytic Astrocytoma.Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group.PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma.BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper.BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2.Analysis of the BRAF(V600E) Mutation in Central Nervous System Tumors.Pediatric gliomas as neurodevelopmental disorders Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects.Challenges in Drug Discovery for Neurofibromatosis Type 1-Associated Low-Grade Glioma Targeting Ras-RAF-ERK and its interactive pathways as a novel therapy for malignant gliomas.Review: low-grade gliomas as neurodevelopmental disorders: insights from mouse models of neurofibromatosis-1.BRAF mutation testing in clinical practice.Long-term epilepsy-associated tumors.Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles.Targeted therapy in pediatric low-grade glioma.Improving outcomes for neurofibromatosis 1-associated brain tumors.Review of low-grade gliomas in children--evolving molecular era and therapeutic insights.Current Understanding of BRAF Alterations in Diagnosis, Prognosis, and Therapeutic Targeting in Pediatric Low-Grade Gliomas.Genetic changes observed in a case of adult pilocytic astrocytoma revealed by array CGH analysis Molecular profiling of gliomas: potential therapeutic implications.Molecular pathology of paediatric central nervous system tumours.Exploration of Involved Key Genes and Signaling Diversity in Brain Tumors.Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma.Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.BRAF-V600E mutation in pediatric and adult glioblastoma.Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma.Something old and something new about molecular diagnostics in gliomas.

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P2860

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

http://www.wikidata.org/entity/Q42636358

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2009 nî lūn-bûn

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2009年论文

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name

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

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Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

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type

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Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

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Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

@nl

prefLabel

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

@en

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

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Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

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D H Gutmann

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F J Rodriguez

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H Deshmukh

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M A Watson

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P2860

The 2007 WHO classification of tumours of the central nervous system

Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas

dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data.

Matrilin-2 expression distinguishes clinically relevant subsets of pilocytic astrocytoma.

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas.

Analysis of pilocytic astrocytoma by comparative genomic hybridization.

New insight into BRAF mutations in cancer.

BRAF(E600) in benign and malignant human tumours.

High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.

Optic pathway tumors in children: the effect of neurofibromatosis type 1 on clinical manifestations and natural history.

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