Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506.
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Acyl-CoA hydrolysis by the high molecular weight protein 1 subunit of yersiniabactin synthetase: mutational evidence for a cascade of four acyl-enzyme intermediates during hydrolytic editingdRNA-seq transcriptional profiling of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis NRRL18488 and general analysis of the transcriptomeGenetic localization and molecular characterization of the nonS gene required for macrotetrolide biosynthesis in Streptomyces griseus DSM40695.Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems.Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae.FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensisBiosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase.Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismateIdentification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS)Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BPA gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.Gobichelin A and B: Mixed-Ligand Siderophores Discovered Using ProteomicsGenome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvementBiosynthesis of rapamycin and its regulation: past achievements and recent progress.Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506).The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects.Cloning and expression of three new Aazotobacter vinelandii genes closely related to a previously described gene family encoding mannuronan C-5-epimerases.FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation.Origin of the allyl group in FK506 biosynthesis.Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit.A new substrate specificity for acyl transferase domains of the ascomycin polyketide synthase in Streptomyces hygroscopicus.A cluster merging method for time series microarray with production values.FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19.Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes.Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis.Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches.Gene clustering for time-series microarray with production outputs
P2860
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P2860
Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Structural organization of a m ...... olide immunosuppressant FK506.
@en
Structural organization of a m ...... olide immunosuppressant FK506.
@nl
type
label
Structural organization of a m ...... olide immunosuppressant FK506.
@en
Structural organization of a m ...... olide immunosuppressant FK506.
@nl
prefLabel
Structural organization of a m ...... olide immunosuppressant FK506.
@en
Structural organization of a m ...... olide immunosuppressant FK506.
@nl
P2093
P2860
P1433
P1476
Structural organization of a m ...... rolide immunosuppressant FK506
@en
P2093
P2860
P356
10.1111/J.1432-1033.1997.00074.X
P407
P577
1997-02-01T00:00:00Z