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Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardiumMyocardial contraction is 5-fold more economical in ventricular than in atrial human tissueIncreased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteinsThe effect of myosin light chain 2 dephosphorylation on Ca2+ -sensitivity of force is enhanced in failing human heartsPhosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytesProtein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardiumImpaired diastolic function after exchange of endogenous troponin I with C-terminal truncated troponin I in human cardiac muscleLength-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylationThe differential effect of propofol on contractility of isolated myocardial trabeculae of rat and guinea-pigATP utilization for calcium uptake and force production in different types of human skeletal muscle fibresA novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysisForce production in mechanically isolated cardiac myocytes from human ventricular muscle tissue.Optical trap stiffness in the presence and absence of spherical aberrations.Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2).Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs.Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy.Unaffected contractility of diaphragm muscle fibers in humans on mechanical ventilationTroponin I phosphorylation in human myocardium in health and disease.Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutationsMore severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease.Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy.Cooperative behavior of molecular motors.Mitochondrial Ca2+-handling in fast skeletal muscle fibers from wild type and calsequestrin-null micePKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol.Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertensionGene expression profile in the diaphragm following contractile inactivity during thoracic surgery.Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patientsMyosin light chain composition in non-failing donor and end-stage failing human ventricular myocardium.Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertensionTension responses to rapid length changes in skinned muscle fibres of the frog.Myofilament degradation and dysfunction of human cardiomyocytes in Fabry disease.Protein kinase A does not alter economy of force maintenance in skinned rat cardiac trabeculae.Size and speed of the working stroke of cardiac myosin in situ.Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.Sarcomeric dysfunction in heart failure.Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension.Titin-based stiffening of muscle fibers in Ehlers-Danlos SyndromeThin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency.
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