The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization.
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The Role of Hedgehog Signaling in Tumor Induced Bone DiseaseKif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesisThe intraflagellar transport protein IFT80 is required for cilia formation and osteogenesisGli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossificationSequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal developmentSOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression.Indian hedgehog signaling regulates transcription and expression of collagen type X via Runx2/Smads interactions.Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway.Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice.mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis.Mesenchymal stem cells overexpressing Ihh promote bone repair.A new role for Hedgehogs in juxtacrine signaling.Constitutive activation of Gli2 impairs bone formation in postnatal growing miceGlobal expression profiling reveals genetic programs underlying the developmental divergence between mouse and human embryogenesis.Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal miceHedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation.Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryoChondrocytic Atf4 regulates osteoblast differentiation and function via Ihh.Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Pathway Is Induced by Mechanical Load and Reduces the Activity of Hedgehog Signaling in Chondrogenic Micromass Cell Cultures.Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal developmentDevelopment of the endochondral skeletonGlioma-associated Oncogene 2 Is Essential for Trophoblastic Fusion by Forming a Transcriptional Complex with Glial Cell Missing-a.Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development.Spop promotes skeletal development and homeostasis by positively regulating Ihh signalingActivation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.Protein kinase inhibitor SU6668 attenuates positive regulation of Gli proteins in cancer and multipotent progenitor cells.Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development.Environmental temperature impact on bone and cartilage growth.WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium.Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation.BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse.WNT7B promotes bone formation in part through mTORC1.mTORC2 signaling promotes skeletal growth and bone formation in mice.Wnt7b can replace Ihh to induce hypertrophic cartilage vascularization but not osteoblast differentiation during endochondral bone development.Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.Gli1 identifies osteogenic progenitors for bone formation and fracture repair.Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice.Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets.Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions.
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The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
The Gli2 transcriptional activ ...... and cartilage vascularization.
@en
The Gli2 transcriptional activ ...... and cartilage vascularization.
@nl
type
label
The Gli2 transcriptional activ ...... and cartilage vascularization.
@en
The Gli2 transcriptional activ ...... and cartilage vascularization.
@nl
prefLabel
The Gli2 transcriptional activ ...... and cartilage vascularization.
@en
The Gli2 transcriptional activ ...... and cartilage vascularization.
@nl
P2860
P356
P1433
P1476
The Gli2 transcriptional activ ...... and cartilage vascularization.
@en
P2093
Fanxin Long
Kyu Sang Joeng
P2860
P304
P356
10.1242/DEV.041624
P407
P577
2009-11-11T00:00:00Z