State-dependent chemical reactivity of an engineered cysteine reveals conformational changes in the outer vestibule of the cystic fibrosis transmembrane conductance regulator.
about
The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function.Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR.Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.Modeling the conformational changes underlying channel opening in CFTRCystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore.Murine and human CFTR exhibit different sensitivities to CFTR potentiators.Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator.Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stabilityPositioning of extracellular loop 1 affects pore gating of the cystic fibrosis transmembrane conductance regulatorMutations at arginine 352 alter the pore architecture of CFTR.Two salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function.Functional architecture of the CFTR chloride channel.Conformational changes opening and closing the CFTR chloride channel: insights from cysteine scanning mutagenesis.Structural Changes Fundamental to Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel Pore.Architecture and functional properties of the CFTR channel pore.Relative movements of transmembrane regions at the outer mouth of the cystic fibrosis transmembrane conductance regulator channel pore during channel gatingRole of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic fibrosis transmembrane conductance regulator chloride channel.Alternating access to the transmembrane domain of the ATP-binding cassette protein cystic fibrosis transmembrane conductance regulator (ABCC7).Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel.Cysteine-independent inhibition of the CFTR chloride channel by the cysteine-reactive reagent sodium (2-sulphonatoethyl) methanethiosulphonate.State-dependent access of anions to the cystic fibrosis transmembrane conductance regulator chloride channel pore.A synthetic prostone activates apical chloride channels in A6 epithelial cells.Relative contribution of different transmembrane segments to the CFTR chloride channel pore.Conformational changes in a pore-lining helix coupled to cystic fibrosis transmembrane conductance regulator channel gating.
P2860
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P2860
State-dependent chemical reactivity of an engineered cysteine reveals conformational changes in the outer vestibule of the cystic fibrosis transmembrane conductance regulator.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
State-dependent chemical react ...... embrane conductance regulator.
@en
State-dependent chemical react ...... embrane conductance regulator.
@nl
type
label
State-dependent chemical react ...... embrane conductance regulator.
@en
State-dependent chemical react ...... embrane conductance regulator.
@nl
prefLabel
State-dependent chemical react ...... embrane conductance regulator.
@en
State-dependent chemical react ...... embrane conductance regulator.
@nl
P2093
P2860
P356
P1476
State-dependent chemical react ...... embrane conductance regulator.
@en
P2093
Binlin Song
Nael A McCarty
Zhi-Ren Zhang
P2860
P304
41997-42003
P356
10.1074/JBC.M510242200
P407
P577
2005-10-14T00:00:00Z