The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity.
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The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxideInhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinaseThe ABC protein turned chloride channel whose failure causes cystic fibrosisCFTR gating II: Effects of nucleotide binding on the stability of open statesCFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).The alternating ATPase domains of MutS control DNA mismatch repairA Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters.Anion transport in heartFunctional asymmetry of the ATP-binding-cassettes of the ABC transporter TAP is determined by intrinsic properties of the nucleotide binding domainsA cluster of negative charges at the amino terminal tail of CFTR regulates ATP-dependent channel gatingPerturbation of the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) inhibits its atpase activity.Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactionsCFTR: break a pump, make a channelStrict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.CFTR channel gating: incremental progress in irreversible steps.Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain.The H-loop in the second nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator is required for efficient chloride channel closingBacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR)Cystic fibrosis transmembrane conductance regulator. Structure and function of an epithelial chloride channel.Direct effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating.CFTR with a partially deleted R domain corrects the cystic fibrosis chloride transport defect in human airway epithelia in vitro and in mouse nasal mucosa in vivoIdentification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment.KATP channels gated by intracellular nucleotides and phospholipids.Human epithelial cystic fibrosis transmembrane conductance regulator without exon 5 maintains partial chloride channel function in intracellular membranes.Structural and functional similarities between the nucleotide-binding domains of CFTR and GTP-binding proteinsCystic fibrosis transmembrane conductance regulator and the outwardly rectifying chloride channel: a relationship between two chloride channels expressed in epithelial cells.Conformation, independent of charge, in the R domain affects cystic fibrosis transmembrane conductance regulator channel openingsThe block of CFTR by scorpion venom is state-dependentMechanism of coupling of transport to hydrolysis in bacterial ATP-binding cassette transportersStatistical evaluation of ion-channel gating models based on distributions of log-likelihood ratios.A conditional probability analysis of cystic fibrosis transmembrane conductance regulator gating indicates that ATP has multiple effects during the gating cycle.Effects of C-terminal deletions on cystic fibrosis transmembrane conductance regulator function in cystic fibrosis airway epitheliaCooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamideCysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS.Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function inHuman-mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR-ΔF508 processing and alter its gating defect.Identification of a novel post-hydrolytic state in CFTR gating.Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation.Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase.
P2860
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P2860
The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
The two nucleotide-binding dom ...... controlling channel activity.
@en
The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator
@nl
type
label
The two nucleotide-binding dom ...... controlling channel activity.
@en
The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator
@nl
prefLabel
The two nucleotide-binding dom ...... controlling channel activity.
@en
The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator
@nl
P2093
P356
P1476
The two nucleotide-binding dom ...... controlling channel activity.
@en
P2093
P304
P356
10.1074/JBC.270.4.1711
P407
P577
1995-01-01T00:00:00Z