Cocaine binds to a common site on open and inactivated human heart (Na(v)1.5) sodium channels.
about
Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmiasState-dependent trapping of flecainide in the cardiac sodium channelFast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental studyCocaine disinhibits dopamine neurons in the ventral tegmental area via use-dependent blockade of GABA neuron voltage-sensitive sodium channelsCocaine inhibition of nicotinic acetylcholine receptors influences dopamine release.Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics.A Literature Review of the Use of Sodium Bicarbonate for the Treatment of QRS Widening.Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.Differential modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by the local anesthetic lidocaine.An inactivation stabilizer of the Na+ channel acts as an opportunistic pore blocker modulated by external Na+.Block of inactivation-deficient Na+ channels by local anesthetics in stably transfected mammalian cells: evidence for drug binding along the activation pathway.State-dependent block of wild-type and inactivation-deficient Na+ channels by flecainide.Involvement of reactive oxygen species in cocaine-taking behaviors in ratsEffects of an epilepsy-causing mutation in the SCN1A sodium channel gene on cocaine-induced seizure susceptibility in mice.Persistent human cardiac Na+ currents in stably transfected mammalian cells: Robust expression and distinct open-channel selectivity among Class 1 antiarrhythmics.Electrocardiographic findings associated with cocaine use in humans: a systematic review.Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels.MTSET modification of D4S6 cysteines stabilize the fast inactivated state of Nav1.5 sodium channels.Molecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine.Bupivacaine blocks N-type inactivating Kv channels in the open state: no allosteric effect on inactivation kinetics.Differential effects of cocaine on dopamine neuron firing in awake and anesthetized rats.Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants.Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels.Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.Structural Models of Ligand-Bound Sodium Channels.A point mutation at F1737 of the human Nav1.7 sodium channel decreases inhibition by local anesthetics.State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261.Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway.
P2860
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P2860
Cocaine binds to a common site on open and inactivated human heart (Na(v)1.5) sodium channels.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Cocaine binds to a common site ...... rt (Na(v)1.5) sodium channels.
@en
Cocaine binds to a common site on open and inactivated human heart
@nl
type
label
Cocaine binds to a common site ...... rt (Na(v)1.5) sodium channels.
@en
Cocaine binds to a common site on open and inactivated human heart
@nl
prefLabel
Cocaine binds to a common site ...... rt (Na(v)1.5) sodium channels.
@en
Cocaine binds to a common site on open and inactivated human heart
@nl
P2860
P1476
Cocaine binds to a common site ...... rt (Na(v)1.5) sodium channels.
@en
P2093
M E O'Leary
P2860
P304
P356
10.1113/JPHYSIOL.2001.016139
P407
P577
2002-06-01T00:00:00Z