A point mutation at F1737 of the human Nav1.7 sodium channel decreases inhibition by local anesthetics.
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Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells.The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development.Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation.Transient impairment of the axolemma following regional anaesthesia by lidocaine in humans.Pain thresholds, supra-threshold pain and lidocaine sensitivity in patients with erythromelalgia, including the I848Tmutation in NaV 1.7.
P2860
A point mutation at F1737 of the human Nav1.7 sodium channel decreases inhibition by local anesthetics.
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name
A point mutation at F1737 of t ...... hibition by local anesthetics.
@en
A point mutation at F1737 of t ...... hibition by local anesthetics.
@nl
type
label
A point mutation at F1737 of t ...... hibition by local anesthetics.
@en
A point mutation at F1737 of t ...... hibition by local anesthetics.
@nl
prefLabel
A point mutation at F1737 of t ...... hibition by local anesthetics.
@en
A point mutation at F1737 of t ...... hibition by local anesthetics.
@nl
P2860
P1476
A point mutation at F1737 of t ...... hibition by local anesthetics.
@en
P2093
Jacqueline Panigel
Sean Peter Cook
P2860
P304
P356
10.3109/01677063.2011.629702
P577
2011-11-10T00:00:00Z