about
Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer modelsGOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancerIntegrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumorsTargeting the PI3K signaling pathway in cancerA genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogeneThe T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATPCo-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.Novel mutant-selective EGFR kinase inhibitors against EGFR T790MThe impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors.Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteinsDNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouseLoss of p53 attenuates the contribution of IL-6 deletion on suppressed tumor progression and extended survival in Kras-driven murine lung cancerA chromatin-mediated reversible drug-tolerant state in cancer cell subpopulationsHIF1α and HIF2α independently activate SRC to promote melanoma metastasesImage-guided radiotherapy platform using single nodule conditional lung cancer mouse modelsSomatic LKB1 mutations promote cervical cancer progression.Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M.Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expressionMitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.Primary tumor genotype is an important determinant in identification of lung cancer propagating cellsLysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.RMRP is a non-coding RNA essential for early murine development.Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLCRationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancerTemporal dissection of K-ras(G12D) mutant in vitro and in vivo using a regulatable K-ras(G12D) mouse alleleLKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling.Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice.Differences underlying EGFR and HER2 oncogene addiction.KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.β-catenin contributes to lung tumor development induced by EGFR mutations
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Kwok Kin Wong
@ast
Kwok Kin Wong
@en
Kwok Kin Wong
@es
Kwok Kin Wong
@nl
Kwok Kin Wong
@sl
type
label
Kwok Kin Wong
@ast
Kwok Kin Wong
@en
Kwok Kin Wong
@es
Kwok Kin Wong
@nl
Kwok Kin Wong
@sl
prefLabel
Kwok Kin Wong
@ast
Kwok Kin Wong
@en
Kwok Kin Wong
@es
Kwok Kin Wong
@nl
Kwok Kin Wong
@sl
P106
P31
P496
0000-0001-6323-235X