Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis - Wikidata - wikimedia - TriplyDB

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

http://www.wikidata.org/entity/Q24609324

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Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8 cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms EVER2 protein binds TRADD to promote TNF-α-induced apoptosis The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2 Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS Poly-ubiquitination in TNFR1-mediated necroptosis Targeting Cell Survival Proteins for Cancer Cell Death Necroptotic Cell Death Signaling and Execution Pathway: Lessons from Knockout Mice DED or alive: assembly and regulation of the death effector domain complexes When ubiquitin meets NF-κB: a trove for anti-cancer drug development Fueling the flames: Mammalian programmed necrosis in inflammatory diseases Small-molecule SMAC mimetics as new cancer therapeutics IAPs: a central element in the NF-κB activating signaling pathway Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer Targeting the apoptosis pathway in hematologic malignancies Programmed necrosis in the cross talk of cell death and inflammation Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2 Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation Recognition of Smac-mimetic compounds by the BIR domain of cIAP1 Regulation of tumour necrosis factor signalling: live or let die NF-κB directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers c-IAP1 and c-IAP2 redundancy differs between T and B cells.A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB.Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment Molecular systems biology of ErbB1 signaling: bridging the gap through multiscale modeling and high-performance computing.Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells.Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer Classical and/or alternative NF-kappaB pathway activation in multiple myeloma.Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis.Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

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Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

http://www.wikidata.org/entity/Q24609324

description

2007 nî lūn-bûn

@nan

2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

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name

Autocrine TNFalpha signaling r ...... Smac-mimetic-induced apoptosis

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Autocrine TNFalpha signaling r ...... Smac-mimetic-induced apoptosis

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Autocrine TNFalpha signaling r ...... Smac-mimetic-induced apoptosis

@nl

type

label

Autocrine TNFalpha signaling r ...... Smac-mimetic-induced apoptosis

@ast

Autocrine TNFalpha signaling r ...... Smac-mimetic-induced apoptosis

@en

Autocrine TNFalpha signaling r ...... Smac-mimetic-induced apoptosis

@nl

prefLabel

Autocrine TNFalpha signaling r ...... Smac-mimetic-induced apoptosis

@ast

Autocrine TNFalpha signaling r ...... Smac-mimetic-induced apoptosis

@en

Autocrine TNFalpha signaling r ...... Smac-mimetic-induced apoptosis

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J.CCR.2007.08.029

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Autocrine TNFalpha signaling r ...... Smac-mimetic-induced apoptosis

@en

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Asligul Yalcin-Chin

http://www.w3.org/2001/XMLSchema#string

John Minna

http://www.w3.org/2001/XMLSchema#string

Lai Wang

http://www.w3.org/2001/XMLSchema#string

Lin Li

http://www.w3.org/2001/XMLSchema#string

Michael Peyton

http://www.w3.org/2001/XMLSchema#string

Patrick Harran

http://www.w3.org/2001/XMLSchema#string

Sean L Petersen

http://www.w3.org/2001/XMLSchema#string

Xiaodong Wang

http://www.w3.org/2001/XMLSchema#string

P2860

The Hallmarks of Cancer

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

X-linked IAP is a direct inhibitor of cell-death proteases

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Structural basis of IAP recognition by Smac/DIABLO

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445-56

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1901152

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10.1016/J.CCR.2007.08.029

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5

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12

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2007-11-01T00:00:00Z

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5849573

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17996648

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apoptotic process

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3431210

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