p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.
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p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodiesp62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver CancerDownregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia.A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer.Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2.Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant β-catenin.Recent insights into the function of autophagy in cancer.p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment.p62 in Cancer: Signaling Adaptor Beyond AutophagyAutophagy in chronic liver diseases: the two faces of Janus.Autophagy in the liver: functions in health and disease.Target acquired: Selective autophagy in cardiometabolic disease.Expanding perspectives on the significance of mitophagy in cancer.Metabolism shapes the tumor microenvironment.Nutrition, inflammation and cancer.Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome.Tumor SQSTM1 (p62) expression and T cells in colorectal cancer.Atg9b Deficiency Suppresses Autophagy and Potentiates Endoplasmic Reticulum Stress-Associated Hepatocyte Apoptosis in Hepatocarcinogenesis.Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy- and p62-dependent manners.Chaperone-mediated autophagy compensates for impaired macroautophagy in the cirrhotic liver to promote hepatocellular carcinomaLiver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.Regulation of Glycolytic Metabolism by Autophagy in Liver Cancer Involves Selective Autophagic Degradation of HK2 (hexokinase 2).p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses.ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma.Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities.Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame.Nrf2, the Master Regulator of Anti-Oxidative Responses.Lipotoxicity induces hepatic protein inclusions through TBK1-mediated p62/SQSTM1 phosphorylation.DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma.IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways.Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation.S100A4 promotes lung tumor development through β-catenin pathway-mediated autophagy inhibition.Predictive and preventive significance of AMPK activation on hepatocarcinogenesis in patients with liver cirrhosis.HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers.[Autophagy in chronic liver diseases: a friend rather than a foe?]Nrf2 and Keap1 abnormalities in esophageal squamous cell carcinoma and association with the effect of chemoradiotherapy.The Clinical Influence of Autophagy-Associated Proteins on Human Lung Cancer.
P2860
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P2860
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh
2016年學術文章
@zh-hant
name
p62, Upregulated during Preneo ...... Stressed HCC-Initiating Cells.
@en
p62, Upregulated during Preneo ...... Stressed HCC-Initiating Cells.
@nl
type
label
p62, Upregulated during Preneo ...... Stressed HCC-Initiating Cells.
@en
p62, Upregulated during Preneo ...... Stressed HCC-Initiating Cells.
@nl
prefLabel
p62, Upregulated during Preneo ...... Stressed HCC-Initiating Cells.
@en
p62, Upregulated during Preneo ...... Stressed HCC-Initiating Cells.
@nl
P2093
P2860
P50
P1433
P1476
p62, Upregulated during Preneo ...... Stressed HCC-Initiating Cells.
@en
P2093
Angeles Duran
Atsushi Umemura
Ekihiro Seki
Hayato Nakagawa
Joan Font-Burgada
Jorge Moscat
Juan F Linares
Kanji Yamaguchi
Koji Taniguchi
P2860
P304
P356
10.1016/J.CCELL.2016.04.006
P577
2016-05-05T00:00:00Z