TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. - Wikidata - wikimedia - TriplyDB

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.

http://www.wikidata.org/entity/Q42736886

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Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice.Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury.TREM2 in Neurodegenerative Diseases.TREM2-Ligand Interactions in Health and Disease.A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides.Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease Inflammation in Alzheimer's disease: Lessons learned from microglia-depletion models.Neurodegeneration: From cellular concepts to clinical applications.Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.Tau Spread, Apolipoprotein E, Inflammation, and More: Rapidly Evolving Basic Science in Alzheimer Disease.Targeting neuroinflammation in Alzheimer's disease: evidence for NSAIDs and novel therapeutics.TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer's disease.TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants.Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease.Microglia and macrophages in brain homeostasis and disease.Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.Protocol for Primary Microglial Culture Preparation.Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia.Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy.Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer's Disease Pathology in Down Syndrome.Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology.Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice.Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan.Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation.

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.

http://www.wikidata.org/entity/Q42736886

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name

TREM2 Haplodeficiency in Mice ...... n and Severe Axonal Dystrophy.

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TREM2 Haplodeficiency in Mice ...... n and Severe Axonal Dystrophy.

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TREM2 Haplodeficiency in Mice ...... n and Severe Axonal Dystrophy.

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TREM2 Haplodeficiency in Mice ...... n and Severe Axonal Dystrophy.

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TREM2 Haplodeficiency in Mice ...... n and Severe Axonal Dystrophy.

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TREM2 Haplodeficiency in Mice ...... n and Severe Axonal Dystrophy.

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David Baddeley

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Jaime Grutzendler

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Peng Yuan

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Yaming Wang

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P2860

In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques.

TREM2 Variants in Alzheimer's Disease

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease

Fibrillar amyloid plaque formation precedes microglial activation

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

ATP mediates rapid microglial response to local brain injury in vivo

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