R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study - Wikidata - wikimedia - TriplyDB

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

http://www.wikidata.org/entity/Q27345528

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TREM2 in CNS homeostasis and neurodegenerative disease Regulation of microglial survival and proliferation in health and diseases.Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech.Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.Soluble TREM2 induces inflammatory responses and enhances microglial survival.TREM2 in Neurodegenerative Diseases.Novel susceptibility loci for Alzheimer's disease.Does the Interplay Between Aging and Neuroinflammation Modulate Alzheimer's Disease Clinical Phenotypes? A Clinico-Pathological Perspective.NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease.Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases.From Common to Rare Variants: The Genetic Component of Alzheimer Disease.Extracellular Mitochondria and Mitochondrial Components Act as Damage-Associated Molecular Pattern Molecules in the Mouse Brain.The Impact of UNC5C Genetic Variations on Neuroimaging in Alzheimer's Disease.Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease.TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.Intracellular trafficking of TREM2 is regulated by presenilin 1.Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review.TREM2 expression in the human brain: a marker of monocyte recruitment?Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).Genetics of dementia in a Finnish cohort.Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.The role of UNC5C in Alzheimer’s disease.

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R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

http://www.wikidata.org/entity/Q27345528

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2015 nî lūn-bûn

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2015年の論文

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Chang-En Yu

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Irina Kurtz

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Kostantin Kiianitsa

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Malia Rumbaugh

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Mark Matsushita

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P2860

TREM2 Variants in Alzheimer's Disease

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder

Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology

Neuropathological stageing of Alzheimer-related changes

Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

A copy number variation morbidity map of developmental delay

Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS).

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Alzheimer's disease

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