Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.
about
Role of calcium-dependent protein kinases in chronic myeloid leukemia: combined effects of PKC and BCR-ABL signaling on cellular alterations during leukemia developmentThe tumor microenvironment shapes hallmarks of mature B-cell malignancies.Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor MicroenvironmentThe pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemiaPKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL.B-cell receptor signaling as a driver of lymphoma development and evolution.Constitutive activation of NF-κB signaling by NOTCH1 mutations in chronic lymphocytic leukemia.Cancer associated fibroblasts in hematological malignancies.Induction of heme oxygenase-1 by Na+-H+ exchanger 1 protein plays a crucial role in imatinib-resistant chronic myeloid leukemia cells.Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblastsEndogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation.Bone marrow stroma-induced resistance of chronic lymphocytic leukemia cells to arsenic trioxide involves Mcl-1 upregulation and is overcome by inhibiting the PI3Kδ or PKCβ signaling pathwaysExtracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia.The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-κB activation and induces apoptosis in chronic lymphocytic leukemia B cells.Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity.Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance.Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity.Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia.Protein kinase C and cancer: what we know and what we do not.Regulation of hematopoiesis by activators and inhibitors of Wnt signaling from the niche.Protein kinase C in cellular transformation: a valid target for therapy?New therapies in non-Hodgkin lymphoma.Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment.Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced MicroenvironmentThe molecular pathogenesis of chronic lymphocytic leukaemia.Stroma-Derived Connective Tissue Growth Factor Maintains Cell Cycle Progression and Repopulation Activity of Hematopoietic Stem Cells In Vitro.NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms.Genomewide RNAi screen identifies protein kinase Cb and new members of mitogen-activated protein kinase pathway as regulators of melanoma cell growth and metastasis.Mechanisms of Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia.In vivo hematopoietic Myc activation directs a transcriptional signature in endothelial cells within the bone marrow microenvironment.Transcriptional mechanism of vascular endothelial growth factor-induced expression of protein kinase CβII in chronic lymphocytic leukaemia cells.Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells.Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCα subversion induces up-regulation of PKCβII expression in B lymphocytes.Chronic lymphocytic leukemia cells are active participants in microenvironmental cross-talk.Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor.Inhibition of focal adhesion kinase overcomes resistance of mantle cell lymphoma to ibrutinib in the bone marrow microenvironment.Potent anti-leukemic activity of a specific cyclin-dependent kinase 9 inhibitor in mouse models of chronic lymphocytic leukemia.Effects of rheumatoid arthritis associated transcriptional changes on osteoclast differentiation network in the synoviumNotch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemiaCXCR4- and BCR-triggered integrin activation in B-cell chronic lymphocytic leukemia cells depends on JAK2-activated Bruton's tyrosine kinase
P2860
Q26861674-AE42CD80-085E-43F2-BE4F-D284FB57BFE7Q27687567-A20FC637-9238-4006-96E8-9E5480140322Q28073613-6589BB29-2418-430A-A297-F3EF94619681Q33655756-F9044F86-8CD0-4862-AE7D-F6D201825C93Q34106863-4C8C31C1-A0B3-44E0-9C07-1E2D9B84EF94Q34398579-D3ED8ADB-3F70-4398-8BA7-0C6C14536750Q35172559-64C189B8-95FA-48C6-AEFE-074CAAA38062Q35550041-EA2126BD-B6A1-4A60-AA34-1267223A0DEEQ35608071-FC2B08E6-C55D-49E3-AD56-385ECDAEC06AQ36028740-489F1115-7D34-4606-A0B0-6D5BDA21B598Q36646371-3B7902EA-FB02-4752-B0A6-387F440B03A9Q36689108-FC948A93-1C31-4F53-8280-9E409ACD0261Q37636979-FDFE74D0-79EE-4D83-91B9-DF4A5EB3B21BQ37649732-E168056C-CDC9-4B5B-8625-1F5B6E84E420Q37683837-DA885E17-075B-41B0-B0A1-C0809F36EFCCQ37723478-EABD26BE-8AE3-4F72-8E61-3D4E883EFB0BQ38108353-4BDF1959-433A-4D43-B316-4A913891D195Q38156717-76D8BE37-A6E5-4F23-A210-BAE17C900C0AQ38171231-7A2F4F46-8BE1-4DC7-8A9C-B081A0BDCD28Q38194615-C2737188-775F-43BD-AD9F-BCCFAF159783Q38268442-B9599EB0-CF2B-4BCD-A2F3-0A1D50CF242AQ38315779-0105FE26-9192-464D-BF59-A346A77E1E6BQ38550810-9274D07A-1129-4496-AC32-BF187CAB517FQ38715717-3ABC8FC9-9F0E-4614-899B-3FF873F79757Q38748645-2CD461F4-0306-4390-9305-DF0348EECF99Q38822690-2C3941F7-D65A-4061-BA77-14EC165F561FQ38988815-9D09C937-C01D-4FB3-A728-05C5621DE9C9Q39035993-F86E18E9-4AB1-4ECA-8925-646EBE431C60Q39169789-22F27D0D-271D-4FF7-BE89-0B4F49B51C0AQ41893555-086A1061-5B58-4954-931B-DAD731D406C1Q42320170-D6E2814F-AB83-44DA-ADD1-A1BCF0201CE9Q42361976-0324BD54-D467-49D9-A889-3A1D3FEC5194Q42660759-046ACEB9-91E1-4D0B-B9B1-90C99BC7EED7Q46011813-49B3F857-A02E-4024-AD88-D702C13C12B2Q46313622-A2BCD0E5-37E0-4AB5-9B01-C2591302EE52Q47699487-8A1CDB9F-C074-4DF2-86AD-EE01C0E35BE2Q55280895-D255CD63-743D-4969-8DA6-380F68EBA045Q57476671-EF32F3E4-2119-4A5B-99A1-8EB2A9A08075Q58705625-FDCCA586-8099-4B19-804C-1026FA255DF6Q58738700-D11206D1-2305-4FA6-8B5F-614B440D589D
P2860
Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh
2013年學術文章
@zh-hant
name
Protein kinase c-β-dependent a ...... ytic leukemia B cells in vivo.
@en
Protein kinase c-β-dependent a ...... ytic leukemia B cells in vivo.
@nl
type
label
Protein kinase c-β-dependent a ...... ytic leukemia B cells in vivo.
@en
Protein kinase c-β-dependent a ...... ytic leukemia B cells in vivo.
@nl
prefLabel
Protein kinase c-β-dependent a ...... ytic leukemia B cells in vivo.
@en
Protein kinase c-β-dependent a ...... ytic leukemia B cells in vivo.
@nl
P2093
P2860
P50
P921
P1433
P1476
Protein kinase c-β-dependent a ...... cytic leukemia B cells in vivo
@en
P2093
Alexander Kohlmann
Andrew J Finch
Benedikt Lampl
Christian Peschel
Claudia Haferlach
Gloria Lutzny
Jürgen Ruland
Ludger Klein-Hitpass
Marc Schmidt-Supprian
P2860
P356
10.1016/J.CCR.2012.12.003
P577
2013-01-01T00:00:00Z