The epidermal growth factor homology domain of the LDL receptor drives lipoprotein release through an allosteric mechanism involving H190, H562, and H586.
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Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pHLDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeatThe closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosomeCavin-3 dictates the balance between ERK and Akt signaling.Model of human low-density lipoprotein and bound receptor based on cryoEMApolipoprotein E: from lipid transport to neurobiologyRole of an intramolecular contact on lipoprotein uptake by the LDL receptorQuantitative fluorescence imaging reveals point of release for lipoproteins during LDLR-dependent uptake.S-nitrosylation of ARH is required for LDL uptake by the LDL receptor.The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.Receptor-associated protein (RAP) has two high-affinity binding sites for the low-density lipoprotein receptor-related protein (LRP): consequences for the chaperone functions of RAP.The role of calcium in lipoprotein release by the low-density lipoprotein receptor.Exploring the complete mutational space of the LDL receptor LA5 domain using molecular dynamics: linking SNPs with disease phenotypes in familial hypercholesterolemia.Identification of roles for H264, H306, H439, and H635 in acid-dependent lipoprotein release by the LDL receptor.Structural changes induced by acidic pH in human apolipoprotein B-100.Domain swapping reveals that low density lipoprotein (LDL) type A repeat order affects ligand binding to the LDL receptor.Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor.Low pH-triggered beta-propeller switch of the low-density lipoprotein receptor assists rhinovirus infection.Low-density lipoprotein receptor is a calcium/magnesium sensor - role of LR4 and LR5 ion interaction kinetics in low-density lipoprotein release in the endosome
P2860
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P2860
The epidermal growth factor homology domain of the LDL receptor drives lipoprotein release through an allosteric mechanism involving H190, H562, and H586.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The epidermal growth factor ho ...... nvolving H190, H562, and H586.
@en
The epidermal growth factor ho ...... nvolving H190, H562, and H586.
@nl
type
label
The epidermal growth factor ho ...... nvolving H190, H562, and H586.
@en
The epidermal growth factor ho ...... nvolving H190, H562, and H586.
@nl
prefLabel
The epidermal growth factor ho ...... nvolving H190, H562, and H586.
@en
The epidermal growth factor ho ...... nvolving H190, H562, and H586.
@nl
P2860
P356
P1476
The epidermal growth factor ho ...... nvolving H190, H562, and H586.
@en
P2093
Peter Michaely
Zhenze Zhao
P2860
P304
26528-26537
P356
10.1074/JBC.M804624200
P407
P577
2008-08-03T00:00:00Z