The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells.
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Lactate regulates rat male germ cell function through reactive oxygen speciesLactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cellsSupply and demand in cerebral energy metabolism: the role of nutrient transportersLactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic RelevanceLactic acid is a sperm motility inactivation factor in the sperm storage tubulesTransporters at CNS barrier sites: obstacles or opportunities for drug delivery?The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transportersOn metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancerHypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symportersBasigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)Transport of lactate and pyruvate in the intraerythrocytic malaria parasite, Plasmodium falciparumCrucial residue involved in L-lactate recognition by human monocarboxylate transporter 4 (hMCT4)Capturing intracellular pH dynamics by coupling its molecular mechanisms within a fully tractable mathematical modelThe inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary proteinStudies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycleAR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in miceTissue-specific expression of monocarboxylate transporters during fasting in mice.Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come.Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using 1H-[13C]-NMRAnalysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.Immunohistochemical analysis of MCT1, MCT2 and MCT4 expression in rat plantaris muscle.The tegument of the human parasitic worm Schistosoma mansoni as an excretory organ: the surface aquaporin SmAQP is a lactate transporter.Evaluation of 2-[¹⁸F]fluoroacetate kinetics in rodent models of cerebral hypoxia-ischemiaIntratumoral lactate metabolism in Barrett's esophagus and adenocarcinoma.Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation.High-amylose resistant starch increases hormones and improves structure and function of the gastrointestinal tract: a microarray study.Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumorsMCT expression and lactate influx/efflux in tanycytes involved in glia-neuron metabolic interaction.Role of monocarboxylate transporters in drug delivery to the brain.CD147 required for corneal endothelial lactate transport.Anticancer targets in the glycolytic metabolism of tumors: a comprehensive reviewA role for nonsense-mediated mRNA decay in plants: pathogen responses are induced in Arabidopsis thaliana NMD mutants.The monocarboxylate transporter family--Structure and functional characterization.White blood cell differentials enrich whole blood expression data in the context of acute cardiac allograft rejectionThe plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.Kinetic analysis and design of experiments to identify the catalytic mechanism of the monocarboxylate transporter isoforms 4 and 1.On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate.Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II.Significant molecular and systemic adaptations after repeated sprint training in hypoxia.
P2860
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P2860
The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
The low-affinity monocarboxyla ...... te in highly glycolytic cells.
@en
The low-affinity monocarboxyla ...... te in highly glycolytic cells.
@nl
type
label
The low-affinity monocarboxyla ...... te in highly glycolytic cells.
@en
The low-affinity monocarboxyla ...... te in highly glycolytic cells.
@nl
prefLabel
The low-affinity monocarboxyla ...... te in highly glycolytic cells.
@en
The low-affinity monocarboxyla ...... te in highly glycolytic cells.
@nl
P2093
P2860
P1433
P1476
The low-affinity monocarboxyla ...... te in highly glycolytic cells.
@en
P2093
P2860
P304
P356
10.1042/0264-6021:3500219
P407
P478
P577
2000-08-01T00:00:00Z