An S101P substitution in the putative cleavage motif of the human metapneumovirus fusion protein is a major determinant for trypsin-independent growth in vero cells and does not alter tissue tropism in hamsters.
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Human Metapneumovirus: lessons learned over the first decadeCell Type-Specific Recognition of Human Metapneumoviruses (HMPVs) by Retinoic Acid-Inducible Gene I (RIG-I) and TLR7 and Viral Interference of RIG-I Ligand Recognition by HMPV-B1 PhosphoproteinDisease-promoting effects of type I interferons in viral, bacterial, and coinfectionsInterferon γ-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA virusesSmall Animal Models for Human Metapneumovirus: Cotton Rat is More Permissive than Hamster and Mouse.Modification of the trypsin-dependent cleavage activation site of the human metapneumovirus fusion protein to be trypsin independent does not increase replication or spread in rodents or nonhuman primates.Characterization of human metapneumovirus infection of myeloid dendritic cellsEngineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation.Trypsin- and low pH-mediated fusogenicity of avian metapneumovirus fusion proteins is determined by residues at positions 100, 101 and 294.Potential electrostatic interactions in multiple regions affect human metapneumovirus F-mediated membrane fusion.Live vaccines for human metapneumovirus designed by reverse genetics.Low-pH triggering of human metapneumovirus fusion: essential residues and importance in entry.A live attenuated human metapneumovirus vaccine strain provides complete protection against homologous viral infection and cross-protection against heterologous viral infection in BALB/c mice.Evidence for the interaction of the human metapneumovirus G and F proteins during virus-like particle formation.Viral entry mechanisms: the increasing diversity of paramyxovirus entry.TMPRSS12 Is an Activating Protease for Subtype B Avian Metapneumovirus.Residues of the human metapneumovirus fusion (F) protein critical for its strain-related fusion phenotype: implications for the virus replication cycle.Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters.Characterization of human metapneumovirus F protein-promoted membrane fusion: critical roles for proteolytic processing and low pH.Development and optimization of a direct plaque assay for human and avian metapneumovirusesThe conserved YAGL motif in human metapneumovirus is required for higher-order cellular assemblies of the matrix protein and for virion production.A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge.Effect of amino acid sequence variations at position 149 on the fusogenic activity of the subtype B avian metapneumovirus fusion protein.Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2.Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years
P2860
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P2860
An S101P substitution in the putative cleavage motif of the human metapneumovirus fusion protein is a major determinant for trypsin-independent growth in vero cells and does not alter tissue tropism in hamsters.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
An S101P substitution in the p ...... er tissue tropism in hamsters.
@en
An S101P substitution in the p ...... er tissue tropism in hamsters.
@nl
type
label
An S101P substitution in the p ...... er tissue tropism in hamsters.
@en
An S101P substitution in the p ...... er tissue tropism in hamsters.
@nl
prefLabel
An S101P substitution in the p ...... er tissue tropism in hamsters.
@en
An S101P substitution in the p ...... er tissue tropism in hamsters.
@nl
P2093
P2860
P1433
P1476
An S101P substitution in the p ...... er tissue tropism in hamsters.
@en
P2093
Jasmine Kaur
Jeanne H Schickli
Nancy Ulbrandt
Richard R Spaete
Roderick S Tang
P2860
P304
10678-10689
P356
10.1128/JVI.79.16.10678-10689.2005
P407
P577
2005-08-01T00:00:00Z