Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2. - Wikidata - wikimedia - TriplyDB

Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2.

Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2.

http://www.wikidata.org/entity/Q42259941

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A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium.Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2.The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.Studies of culture conditions and environmental stability of human metapneumovirus.Detection of Middle East respiratory syndrome coronavirus using reverse transcription loop-mediated isothermal amplification (RT-LAMP).TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells.Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation.Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response.Role of proteases in the release of porcine epidemic diarrhea virus from infected cells.The SI strain of measles virus derived from a patient with subacute sclerosing panencephalitis possesses typical genome alterations and unique amino acid changes that modulate receptor specificity and reduce membrane fusion activity.Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease Impact of host proteases on reovirus infection in the respiratory tract.Human metapneumovirus (HMPV) binding and infection are mediated by interactions between the HMPV fusion protein and heparan sulfate.Paramyxovirus fusion and entry: multiple paths to a common end Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation.Breaking in: human metapneumovirus fusion and entry The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies.The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.Low-pH triggering of human metapneumovirus fusion: essential residues and importance in entry.Proteolytic activation of the 1918 influenza virus hemagglutinin.TMPRSS2 is an activating protease for respiratory parainfluenza viruses.Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2.Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay.TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice.Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium.Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor TMPRSS12 Is an Activating Protease for Subtype B Avian Metapneumovirus.TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells.Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection.Residues of the human metapneumovirus fusion (F) protein critical for its strain-related fusion phenotype: implications for the virus replication cycle.TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation.

P2860

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P2860

Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2.

http://www.wikidata.org/entity/Q42259941

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Efficient multiplication of hu ...... brane serine protease TMPRSS2.

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Efficient multiplication of hu ...... brane serine protease TMPRSS2.

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type

label

Efficient multiplication of hu ...... brane serine protease TMPRSS2.

@en

Efficient multiplication of hu ...... brane serine protease TMPRSS2.

@nl

prefLabel

Efficient multiplication of hu ...... brane serine protease TMPRSS2.

@en

Efficient multiplication of hu ...... brane serine protease TMPRSS2.

@nl

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Journal of Virology

P1476

Efficient multiplication of hu ...... brane serine protease TMPRSS2.

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P2093

Hideaki Kikuta

http://www.w3.org/2001/XMLSchema#string

Hiroki Takeuchi

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Maino Tahara

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Makoto Takeda

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Masaharu Iwasaki

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Nobuhisa Ishiguro

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Yuichiro Nakatsu

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Yusuke Yanagi

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Yuta Shirogane

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P2860

Cloning and characterization of the cDNA for human airway trypsin-like protease

Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3

The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells

Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium

Efficient selection for high-expression transfectants with a novel eukaryotic vector

Role of hemagglutinin cleavage for the pathogenicity of influenza virus.

A newly discovered human pneumovirus isolated from young children with respiratory tract disease.

Cleavage of the human respiratory syncytial virus fusion protein at two distinct sites is required for activation of membrane fusion.

Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.

Long untranslated regions of the measles virus M and F genes control virus replication and cytopathogenicity

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8942-8946

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10.1128/JVI.00676-08

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17

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82

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2008-06-18T00:00:00Z

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5293230

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18562527

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transmembrane protein

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2519639

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