about
Diverting a protein from its cellular location by intracellular antibodies. The case of p21Ras.Aggresome formation by anti-Ras intracellular scFv fragments. The fate of the antigen-antibody complex.Functional analysis and molecular dynamics simulation of LOX-1 K167N polymorphism reveal alteration of receptor activity.The selection of intracellular antibodies.Selective re-routing of prion protein to proteasomes and alteration of its vesicular secretion prevent PrP(Sc) formation.The potential of intracellular antibodies for therapeutic targeting of protein-misfolding diseases.Molecular mechanism of statin-mediated LOX-1 inhibition.Nerve growth factor inhibits the synthesis of a single-stranded DNA binding protein in pheochromocytoma cells (clone PC12).Human recombinant antibody fragments neutralizing human immunodeficiency virus type 1 reverse transcriptase provide an experimental basis for the structural classification of the DNA polymerase family.The lectin-like oxidized LDL receptor-1: a new potential molecular target in colorectal cancerCombating protein misfolding and aggregation by intracellular antibodies.Gene-based antibody strategies for prion diseases.Therapeutic application of intrabodies against age-related neurodegenerative disorders.Membrane Cholesterol Modulates LOX-1 Shedding in Endothelial CellsDNA hairpins promote temperature controlled cargo encapsulation in a truncated octahedral nanocage structure family.The nerve growth factor. Established findings and controversial aspects.Trapping prion protein in the endoplasmic reticulum impairs PrPC maturation and prevents PrPSc accumulation.Intracellular targeting and functional analysis of single-chain Fv fragments in mammalian cells.Intrabody-mediated diverting of HP1β to the cytoplasm induces co-aggregation of H3-H4 histones and lamin-B receptor.Assembled IgG molecules are exported from the endoplasmic reticulum in myeloma cells despite the retention signal SEKDEL.Evidence for proteasome dysfunction in cytotoxicity mediated by anti-Ras intracellular antibodies.Can intrabodies targeted to the secretory compartment interact with a cytosolic protein? A comment on the article by Sawahata et al. "Cytoplasmic expression and specific binding of the VH/VL single domain intrabodies in transfected NIH3T3 cells",Loss of heterochromatin protein 1 (HP1) chromodomain function in mammalian cells by intracellular antibodies causes cell death.The mode of action of Y13-259 scFv fragment intracellularly expressed in mammalian cells.Nuclear localization of a lactic dehydrogenase with single-stranded DNA-binding properties.Preparation of highly 3H-labeled S-100 protein under nondenaturing conditions.In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction.Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy.KDEL-tagged anti-prion intrabodies impair PrP lysosomal degradation and inhibit scrapie infectivity.The splice variant LOXIN inhibits LOX-1 receptor function through hetero-oligomerization.Simulative and experimental investigation on the cleavage site that generates the soluble human LOX-1.Cholesterol-lowering drugs inhibit lectin-like oxidized low-density lipoprotein-1 receptor function by membrane raft disruption.Design of a novel LOX-1 receptor antagonist mimicking the natural substrate.Redox state of single chain Fv fragments targeted to the endoplasmic reticulum, cytosol and mitochondria.Altered intracellular distribution of PrPC and impairment of proteasome activity in tau overexpressing cortical neurons.Intracellular immunization with cytosolic recombinant antibodies.Intracellular expression of anti-p21ras single chain Fv fragments inhibits meiotic maturation of xenopus oocytes.Selective targeting and degradation of doxorubicin-loaded folate-functionalized DNA nanocages.'Phytoantibodies': a general vector for the expression of immunoglobulin domains in transgenic plants.Hidden receptors for nerve growth factor in PC12 cells.
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description
hulumtuese
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onderzoeker
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հետազոտող
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name
Silvia Biocca
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Silvia Biocca
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Silvia Biocca
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Silvia Biocca
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Silvia Biocca
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type
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Silvia Biocca
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Silvia Biocca
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Silvia Biocca
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Silvia Biocca
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Silvia Biocca
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Silvia Biocca
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Silvia Biocca
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Silvia Biocca
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Silvia Biocca
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Silvia Biocca
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