Chemical modifications in therapeutic protein aggregates generated under different stress conditions.
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Classification and characterization of therapeutic antibody aggregates.Therapeutic protein aggregation: mechanisms, design, and control.Detection and characterization of subvisible aggregates of monoclonal IgG in serumUse of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based BiotherapeuticsChemical modifications in aggregates of recombinant human insulin induced by metal-catalyzed oxidation: covalent cross-linking via michael addition to tyrosine oxidation products.Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responsesA new approach to quantification of mAb aggregates using peptide affinity probes.Silk-based stabilization of biomacromolecules.Structural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting.Identification of oxidation sites and covalent cross-links in metal catalyzed oxidized interferon Beta-1a: potential implications for protein aggregation and immunogenicityAcid-induced aggregation propensity of nivolumab is dependent on the Fc.Minimizing immunogenicity of biopharmaceuticals by controlling critical quality attributes of proteins.Oxidation of therapeutic proteins and peptides: structural and biological consequences.Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges.Forced degradation studies: current trends and future perspectives for protein-based therapeutics.Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbsEffect of arginine on pre-nucleus stage of interferon beta-1b aggregationStructural characterization of IgG1 mAb aggregates and particles generated under various stress conditions.Radar chart array analysis to visualize effects of formulation variables on IgG1 particle formation as measured by multiple analytical techniques.UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences.Physical characterization and in vitro biological impact of highly aggregated antibodies separated into size-enriched populations by fluorescence-activated cell sorting.AlphaScreen-based homogeneous assay using a pair of 25-residue artificial proteins for high-throughput analysis of non-native IgG.Fluorogenic tagging methodology applied to characterize oxidized tyrosine and phenylalanine in an immunoglobulin monoclonal antibody.Chemical and Biophysical Characteristics of Monoclonal Antibody Solutions Containing Aggregates Formed during Metal Catalyzed Oxidation.Nanoparticulate Impurities Isolated from Pharmaceutical-Grade Sucrose Are a Potential Threat to Protein Stability.Photo-oxidation of IgG1 and Model Peptides: Detection and Analysis of Triply Oxidized His and Trp Side Chain Cleavage Products.Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules.Immunogenicity of protein aggregates of a monoclonal antibody generated by forced shaking stress with siliconized and nonsiliconized syringes in BALB/c mice.Sensitive Detection of Immunoglobulin G Stability Using in Real-Time Isothermal Differential Scanning Fluorimetry: Determinants of Protein Stability for Antibody-Based Therapeutics.Using hydrogen peroxide to prevent antibody disulfide bond reduction during manufacturing process.Biosimilarity under stress: A forced degradation study of Remicade® and Remsima™.Evidence for intermolecular domain exchange in the Fab domains of dimer and oligomers of an IgG1 monoclonal antibody.Analytical comparability study of recombinant monoclonal antibody therapeutics.Forced degradation of recombinant monoclonal antibodies: A practical guide.Media photo-degradation in pharmaceutical biotechnology - impact of ambient light on media quality, cell physiology, and IgG production in CHO cultures
P2860
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P2860
Chemical modifications in therapeutic protein aggregates generated under different stress conditions.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Chemical modifications in ther ...... r different stress conditions.
@en
Chemical modifications in ther ...... r different stress conditions.
@nl
type
label
Chemical modifications in ther ...... r different stress conditions.
@en
Chemical modifications in ther ...... r different stress conditions.
@nl
prefLabel
Chemical modifications in ther ...... r different stress conditions.
@en
Chemical modifications in ther ...... r different stress conditions.
@nl
P2093
P2860
P356
P1476
Chemical modifications in ther ...... r different stress conditions.
@en
P2093
Jette Wypych
Linda O Narhi
Marisa K Joubert
Quanzhou Luo
Randal R Ketchem
Riki Stevenson
P2860
P304
25134-25144
P356
10.1074/JBC.M110.160440
P407
P577
2011-04-25T00:00:00Z