Functional analysis of PIK3CA gene mutations in human colorectal cancer.
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Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature ReviewShould individual PI3 kinase isoforms be targeted in cancer?Markers of resistance to anti-EGFR therapy in colorectal cancerDe novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromesThe PI3K pathway as drug target in human cancerEmerging common themes in regulation of PIKKs and PI3KsKnockin of mutant PIK3CA activates multiple oncogenic pathwaysTransforming properties of YAP, a candidate oncogene on the chromosome 11q22 ampliconPI3K and AKT: Unfaithful Partners in CancerEmerging targeted therapies for melanoma treatment (review)Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunitThe structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutationsRegulation of lipid binding underlies the activation mechanism of class IA PI3-kinasesAutoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ IsozymesPIK3CA mutation is associated with poor survival among patients with metastatic colorectal cancer following anti-EGFR monoclonal antibody therapy: a meta-analysis.Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model.Will targeting PI3K/Akt/mTOR signaling work in hematopoietic malignancies?Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cellsThe determinants of head and neck cancer: Unmasking the PI3K pathway mutationsDifferential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA.Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models.High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast.Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas.The PIK3CA gene as a mutated target for cancer therapy.Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS.The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression.Phosphatidylinositol 4,5-bisphosphate-specific AKT1 is oncogenic.PIK3CA mutations and copy number gains in human lung cancers.Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy.Expression of the RAE-1 family of stimulatory NK-cell ligands requires activation of the PI3K pathway during viral infection and transformation.Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alphaRAS Interaction with PI3K: More Than Just Another Effector PathwayPhosphatidylinositol 3-kinase: the oncoprotein.Cancer-specific mutations in PIK3CA are oncogenic in vivoRomidepsin (FK228) and its analogs directly inhibit phosphatidylinositol 3-kinase activity and potently induce apoptosis as histone deacetylase/phosphatidylinositol 3-kinase dual inhibitors.Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatmentAutophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activityRole of E542 and E545 missense mutations of PIK3CA in breast cancer: a comparative computational approach.Population pharmacokinetics and pharmacodynamics of BYL719, a phosphoinositide 3-kinase antagonist, in adult patients with advanced solid malignancies
P2860
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P2860
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
@en
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
@nl
type
label
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
@en
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
@nl
prefLabel
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
@en
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
@nl
P2093
P1433
P1476
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
@en
P2093
Amarsanaa Jazag
Bayasi Guleng
Fumihiko Kanai
Jun Imamura
Keisuke Tateishi
Masao Omata
Masayuki Matsumura
Takao Kawabe
Toshiyuki Obata
P304
P356
10.1158/0008-5472.CAN-04-4114
P407
P577
2005-06-01T00:00:00Z