Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. - Wikidata - wikimedia - TriplyDB

Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.

Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.

http://www.wikidata.org/entity/Q30492318

about

Cancer genome landscapes Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions Phosphoinositides: tiny lipids with giant impact on cell regulation The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data The determinants of head and neck cancer: Unmasking the PI3K pathway mutations The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration PI3K: from the bench to the clinic and back.Human urine-derived stem cells in combination with polycaprolactone/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis.Genetically engineered mouse models of PI3K signaling in breast cancer.Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors Activation of diverse signalling pathways by oncogenic PIK3CA mutations.SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration.AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake.Membrane lipids in invadopodia and podosomes: key structures for cancer invasion and metastasis A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types Functional viability profiles of breast cancer.Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation.Elevated PI3K signaling drives multiple breast cancer subtypes.LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma.PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma.Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.Microenvironmental regulation of epithelial-mesenchymal transitions in cancer The favorable impact of PIK3CA mutations on survival: an analysis of 2587 patients with breast cancer.Signaling via class IA Phosphoinositide 3-kinases (PI3K) in human, breast-derived cell lines Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis.LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells.PI3K: a potential therapeutic target for cancer.Targeting the protein-protein interaction between IRS1 and mutant p110α for cancer therapy.Correlation between PIK3CA mutations in cell-free DNA and everolimus efficacy in HR+, HER2- advanced breast cancer: results from BOLERO-2.Tumor cell intravasation.PIK3CA mutation spectrum in urothelial carcinoma reflects cell context-dependent signaling and phenotypic outputs.Increased cell apoptosis in human lung adenocarcinoma and in vivo tumor growth inhibition by RBM10, a tumor suppressor gene.PIK3CA kinase domain mutation identifies a subgroup of stage III colon cancer patients with poor prognosis.

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P2860

Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.

http://www.wikidata.org/entity/Q30492318

description

2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Differential enhancement of br ...... IA phosphoinositide 3-kinase.

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Differential enhancement of br ...... IA phosphoinositide 3-kinase.

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Differential enhancement of br ...... IA phosphoinositide 3-kinase.

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Differential enhancement of br ...... IA phosphoinositide 3-kinase.

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Differential enhancement of br ...... IA phosphoinositide 3-kinase.

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Differential enhancement of br ...... IA phosphoinositide 3-kinase.

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0008-5472.CAN-09-1968

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Cancer Research

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Differential enhancement of br ...... IA phosphoinositide 3-kinase.

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Anne R Bresnick

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Antonia Patsialou

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Evanthia T Roussos

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Haiyan Wu

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Huan Pang

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Jeffrey E Segall

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Jeffrey Wyckoff

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John S Condeelis

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Jonathan M Backer

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Maria Pozzuto

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P2860

Knockin of mutant PIK3CA activates multiple oncogenic pathways

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.

A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

A third-generation lentivirus vector with a conditional packaging system

A critical step in metastasis: in vivo analysis of intravasation at the primary tumor.

Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods.

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