Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition.
about
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complexSkp2: a novel potential therapeutic target for prostate cancerDeregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerRASSF tumor suppressor gene family: biological functions and regulationDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinomaCullins and cancer.Cullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis.Hippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4.Pathogenic Role of the CRL4 Ubiquitin Ligase in Human DiseaseTargeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage.Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulationProfiling of hepatocellular carcinoma cell cycle regulating genes targeted by calycosin.Mammalian Hippo pathway: from development to cancer and beyond.Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis.The cellular functions of RASSF1A and its inactivation in prostate cancer.RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome?A portrayal of E3 ubiquitin ligases and deubiquitylases in cancer.S-phase kinase-associated protein 2 promotes cell growth and motility in osteosarcoma cells.Recent advances in SCF ubiquitin ligase complex: Clinical implicationsMEK inhibitor effective against proliferation in breast cancer cell.AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/Regulation of APC/CCdc20 activity by RASSF1A-APC/CCdc20 circuitry.Pathogenetic and Prognostic Significance of Inactivation of RASSF Proteins in Human Hepatocellular Carcinoma.The tumor suppressor RASSF10 is upregulated upon contact inhibition and frequently epigenetically silenced in cancer.p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance.Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer.
P2860
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P2860
Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Skp2 regulates the antiprolife ...... dation at the G1-S transition.
@en
Skp2 regulates the antiprolife ...... dation at the G1-S transition.
@nl
type
label
Skp2 regulates the antiprolife ...... dation at the G1-S transition.
@en
Skp2 regulates the antiprolife ...... dation at the G1-S transition.
@nl
prefLabel
Skp2 regulates the antiprolife ...... dation at the G1-S transition.
@en
Skp2 regulates the antiprolife ...... dation at the G1-S transition.
@nl
P2093
P2860
P356
P1433
P1476
Skp2 regulates the antiprolife ...... dation at the G1-S transition.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210971
P407
P50
P577
2007-12-10T00:00:00Z
P5875
P6179
1053144999