The kinetics, substrate and inhibitor specificity of the lactate transporter of Ehrlich-Lettre tumour cells studied with the intracellular pH indicator BCECF.
about
Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient pastThe proton-linked monocarboxylate transporter (MCT) family: structure, function and regulationCharacterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscleIdentification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrateLactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic RelevanceRegulation of monocarboxylic acid transporter-1 by cAMP dependent vesicular trafficking in brain microvascular endothelial cellsBasigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)Lactate and malignant tumors: a therapeutic target at the end stage of glycolysisTransport of lactate and pyruvate in the intraerythrocytic malaria parasite, Plasmodium falciparumImmunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulationStudies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycleAR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transportLactate shuttling and lactate use as fuel after traumatic brain injury: metabolic considerationsFueling and imaging brain activation.Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation.Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter.Regulation of pyruvate metabolism and human diseaseThe monocarboxylate transporter family--Structure and functional characterization.Monocarboxylate transporter 2 and stroke severity in a rodent model of sleep apnea.Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor.Lactate transport and transporters: general principles and functional roles in brain cells.Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function.An In Silico Knockout Model for Gastrointestinal Absorption Using a Systems Pharmacology Approach - Development and Application for Ketones.Accumulation of methylglyoxal and d-lactate in Pb-induced nephrotoxicity in rats.Hyperpolarized 13C NMR observation of lactate kinetics in skeletal muscle.Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition.Inhibition of monocarboxylate transporter 2 in the retrotrapezoid nucleus in rats: a test of the astrocyte-neuron lactate-shuttle hypothesis.Monocarboxylate transporters in the brain and in cancer.Localisation of Lactate Transporters in Rat and Rabbit Placentae.S-Nitrosation of monocarboxylate transporter 1: inhibition of pyruvate-fueled respiration and proliferation of breast cancer cells.Metabolism, compartmentation, transport and production of acetate in the cortical brain tissue slice.Monocarboxylic acid transport.The role of tanycytes in hypothalamic glucosensing.Direct dynamic measurement of intracellular and extracellular lactate in small-volume cell suspensions with (13)C hyperpolarised NMR.β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms.Spin echo measurements of the extravasation and tumor cell uptake of hyperpolarized [1-(13) C]lactate and [1-(13) C]pyruvate.Regulation of Mct1 by cAMP-dependent internalization in rat brain endothelial cells.Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells.
P2860
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P2860
The kinetics, substrate and inhibitor specificity of the lactate transporter of Ehrlich-Lettre tumour cells studied with the intracellular pH indicator BCECF.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
The kinetics, substrate and in ...... racellular pH indicator BCECF.
@en
The kinetics, substrate and in ...... racellular pH indicator BCECF.
@nl
type
label
The kinetics, substrate and in ...... racellular pH indicator BCECF.
@en
The kinetics, substrate and in ...... racellular pH indicator BCECF.
@nl
prefLabel
The kinetics, substrate and in ...... racellular pH indicator BCECF.
@en
The kinetics, substrate and in ...... racellular pH indicator BCECF.
@nl
P2860
P356
P1433
P1476
The kinetics, substrate and in ...... racellular pH indicator BCECF.
@en
P2093
Carpenter L
P2860
P304
P356
10.1042/BJ3040751
P407
P478
304 ( Pt 3)
P577
1994-12-01T00:00:00Z