Geldanamycin-induced destabilization of Raf-1 involves the proteasome.
about
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 functionHSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathwayMeaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsThe Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKRQuercetin-induced ubiquitination and down-regulation of Her-2/neuThe heat shock protein 90 of Plasmodium falciparum and antimalarial activity of its inhibitor, geldanamycinThe role of cullin 5-containing ubiquitin ligasesHsp90 selectively modulates phenotype in vertebrate developmentGeldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperonesHeat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infectionRegulation and role of Raf-1/B-Raf heterodimerization.Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosisGeldanamycin disrupts platelet-membrane structure, leading to membrane permeabilization and inhibition of platelet aggregation.Estradiol-induced phosphorylation of ERK1/2 in explants of the mouse cerebral cortex: the roles of heat shock protein 90 (Hsp90) and MEK2.Opposite effects of the Hsp90 inhibitor Geldanamycin: induction of apoptosis in PC12, and differentiation in N2A cells.Total synthesis of the Hsp90 inhibitor geldanamycin.E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells.Chaperones in cell cycle regulation and mitogenic signal transduction: a review.V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitorsHsp90: chaperoning signal transduction.When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.Stabilization of phosphatidylinositol 4-kinase type IIbeta by interaction with Hsp90Three-dimensional culture regulates Raf-1 expression to modulate fibronectin matrix assemblyThe heat shock response and cytoprotection of the intestinal epithelium.Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy.Heat shock proteins as emerging therapeutic targets.Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation.Chaperone proteins and brain tumors: potential targets and possible therapeutics.A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desertRaf kinases: function, regulation and role in human cancer.Heat-shock protein 90 inhibitors in cancer therapy: 17AAG and beyond.Therapeutic aspects of chaperones/heat-shock proteins in neuro-oncology.Use of radiolabelled choline as a pharmacodynamic marker for the signal transduction inhibitor geldanamycin.Hsp90 is required for pheromone signaling in yeast.Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action.Stability of the Hsp90 inhibitor 17AAG hydroquinone and prevention of metal-catalyzed oxidation.ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1Inhibition of neuroblastoma xenograft growth by Hsp90 inhibitors.Effect of geldanamycin on androgen receptor function and stability.
P2860
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P2860
Geldanamycin-induced destabilization of Raf-1 involves the proteasome.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Geldanamycin-induced destabilization of Raf-1 involves the proteasome.
@en
Geldanamycin-induced destabilization of Raf-1 involves the proteasome.
@nl
type
label
Geldanamycin-induced destabilization of Raf-1 involves the proteasome.
@en
Geldanamycin-induced destabilization of Raf-1 involves the proteasome.
@nl
prefLabel
Geldanamycin-induced destabilization of Raf-1 involves the proteasome.
@en
Geldanamycin-induced destabilization of Raf-1 involves the proteasome.
@nl
P2093
P356
P1476
Geldanamycin-induced destabilization of Raf-1 involves the proteasome.
@en
P2093
P304
P356
10.1006/BBRC.1997.7527
P407
P577
1997-10-01T00:00:00Z