Genistein potentiates wild-type and delta F508-CFTR channel activity.
about
CFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectivesAssessment of CFTR chloride channel openers in intact normal and cystic fibrosis murine epitheliaCurcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implicationsSmall molecule correctors of F508del-CFTR discovered by structure-based virtual screeningDomain-domain associations in cystic fibrosis transmembrane conductance regulator.Spontaneous rescue from cystic fibrosis in a mouse model.The role of the UPS in cystic fibrosis.4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing.Novel pharmacologic therapies for cystic fibrosisCystic fibrosis: exploiting its genetic basis in the hunt for new therapiesDeltaF508 CFTR processing correction and activity in polarized airway and non-airway cell monolayers.Potentiation of disease-associated cystic fibrosis transmembrane conductance regulator mutants by hydrolyzable ATP analogs.Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.Direct effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating.Assessment of swelling-activated Cl- channels using the halide-sensitive fluorescent indicator 6-methoxy-N-(3-sulfopropyl)quinoliniumCalpain inhibition promotes the rescue of F(508)del-CFTR in PBMC from cystic fibrosis patients.Specific inhibition of stretch-induced increase in L-type calcium channel currents by herbimycin A in canine basilar arterial myocytes.Effect of genistein on native epithelial tissue from normal individuals and CF patients and on ion channels expressed in Xenopus oocytesEffect of genistein on basal jejunal chloride secretion in R117H CF mice is sex and route specific.Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells.Genistein stimulates jejunum chloride secretion via an Akt-mediated pathway in intact female mice.Thermally unstable gating of the most common cystic fibrosis mutant channel (ΔF508): "rescue" by suppressor mutations in nucleotide binding domain 1 and by constitutive mutations in the cytosolic loops.CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity.Thermal instability of ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: protection by single suppressor mutations and inhibiting channel activityModulation of Chloride Channel Functions by the Plant Lignan Compounds Kobusin and Eudesmin.Actions of genistein on cystic fibrosis transmembrane conductance regulator channel gating. Evidence for two binding sites with opposite effects.Gating of cystic fibrosis transmembrane conductance regulator chloride channels by adenosine triphosphate hydrolysis. Quantitative analysis of a cyclic gating schemeThe relationship between cAMP, Ca(2)+, and transport of CFTR to the plasma membrane.Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator.Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle.Natural Compounds as Therapeutic Agents in the Treatment Cystic FibrosisStimulation of murine intestinal secretion by daily genistein injections: gender-dependent differencesApplication of high-resolution single-channel recording to functional studies of cystic fibrosis mutants.Molecular modeling of the heterodimer of human CFTR's nucleotide-binding domains using a protein-protein docking approachDevelopment of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function.Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis.Functional Rescue of F508del-CFTR Using Small Molecule CorrectorsThe most common cystic fibrosis-associated mutation destabilizes the dimeric state of the nucleotide-binding domains of CFTR.Failure of cAMP agonists to activate rescued deltaF508 CFTR in CFBE41o- airway epithelial monolayers.
P2860
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P2860
Genistein potentiates wild-type and delta F508-CFTR channel activity.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Genistein potentiates wild-type and delta F508-CFTR channel activity.
@en
Genistein potentiates wild-type and delta F508-CFTR channel activity.
@nl
type
label
Genistein potentiates wild-type and delta F508-CFTR channel activity.
@en
Genistein potentiates wild-type and delta F508-CFTR channel activity.
@nl
prefLabel
Genistein potentiates wild-type and delta F508-CFTR channel activity.
@en
Genistein potentiates wild-type and delta F508-CFTR channel activity.
@nl
P2093
P2860
P1476
Genistein potentiates wild-type and delta F508-CFTR channel activity.
@en
P2093
P2860
P304
P356
10.1152/AJPCELL.1997.273.3.C988
P407
P433
P577
1997-09-01T00:00:00Z