A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.
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Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling UnitsT cell receptor signalling in the control of regulatory T cell differentiation and functionSignaling in T cells - is anything the m(a)TOR with the picture(s)?Disrupted regulatory T cell homeostasis in inflammatory bowel diseasesThe Timing of T Cell Priming and CyclingCIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes InfectionDistinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells.Chemical genetic strategy for targeting protein kinases based on covalent complementarityStructure-Guided Inhibitor Design Expands the Scope of Analog-Sensitive Kinase TechnologyA novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns.Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.Actin polymerization-dependent activation of Cas-L promotes immunological synapse stabilityTumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine.Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling.Generation and characterization of an analog-sensitive PERK allele.A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.Continuous requirement for the TCR in regulatory T cell function.Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy.Regulatory T cells require TCR signaling for their suppressive functionThe catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function.1α,25(OH)2 Vitamin D3 Modulates Avian T Lymphocyte Functions without Inducing CTL Unresponsiveness.A microfluidic platform reveals differential response of regulatory T cells to micropatterned costimulation arrays.Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease.PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysisMimicking transient activation of protein kinases in living cells.Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferationCutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues.Differential response of regulatory and conventional CD4⁺ lymphocytes to CD3 engagement: clues to a possible mechanism of anti-CD3 action?Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTLTCR signaling requirements for activating T cells and for generating memory.Chemical genetics: budding yeast as a platform for drug discovery and mapping of genetic pathways.The role of the cytoskeleton at the immunological synapse.Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation.Origins of the cytolytic synapse.The secret life of kinases: functions beyond catalysisNon-kinase targets of protein kinase inhibitors.TCR signalling network organization at the immunological synapses of murine regulatory T cells.
P2860
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P2860
A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
A genetically selective inhibi ...... ent of its catalytic activity.
@en
A genetically selective inhibi ...... ent of its catalytic activity.
@nl
type
label
A genetically selective inhibi ...... ent of its catalytic activity.
@en
A genetically selective inhibi ...... ent of its catalytic activity.
@nl
prefLabel
A genetically selective inhibi ...... ent of its catalytic activity.
@en
A genetically selective inhibi ...... ent of its catalytic activity.
@nl
P2093
P2860
P356
P1433
P1476
A genetically selective inhibi ...... ent of its catalytic activity.
@en
P2093
Chao Zhang
Debra A Cheng
Kevan M Shokat
Lih-Yun Hsu
Nigel Killeen
Susan E Levin
P2860
P304
P356
10.1038/NI.1955
P407
P577
2010-10-31T00:00:00Z