Essential role for ZAP-70 in both positive and negative selection of thymocytes
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ZAP-70 restoration in mice by in vivo thymic electroporationThe influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activationInteraction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signalingEpithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesisMechanism of activation for Zap-70 catalytic activityThe kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localizationIn vivo correction of ZAP-70 immunodeficiency by intrathymic gene transferPositive and negative regulation of T-cell activation through kinases and phosphatasesDistinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor functionPrimary immunodeficiencies associated with eosinophiliaThymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance InductionThymus, innate immunity and autoimmune arthritis: interplay of gene and environmentAntigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medullaInteractions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cellsTyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activationPhosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor functionThe non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.Murine Schnurri-2 is required for positive selection of thymocytesDifferential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinasesProteomic Signatures of ThymomasRhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte developmentThe Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signalingRasGRP is essential for mouse thymocyte differentiation and TCR signalingDisruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinaseFunctional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicityDAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinaseThe Syk family of protein tyrosine kinases in T-cell activation and developmentThe lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling.Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade.Altered thymic positive selection and intracellular signals in Cbl-deficient miceOverlapping and asymmetric functions of TCR signaling during thymic selection of CD4 and CD8 lineagesIntrathymic transplantation of bone marrow-derived progenitors provides long-term thymopoiesis.Administration of RANKL boosts thymic regeneration upon bone marrow transplantationOrganization of proximal signal initiation at the TCR:CD3 complex.Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases.The GTPase Rho has a critical regulatory role in thymus development.S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes.Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70
P2860
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P248
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P2860
Essential role for ZAP-70 in both positive and negative selection of thymocytes
description
1995 nî lūn-bûn
@nan
1995 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@ast
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@en
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@en-gb
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@nl
type
label
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@ast
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@en
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@en-gb
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@nl
prefLabel
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@ast
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@en
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@en-gb
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@nl
P2093
P921
P3181
P356
P1433
P1476
Essential role for ZAP-70 in both positive and negative selection of thymocytes
@en
P2093
K Nakayama
N Motoyama
S Hatakeyama
P2888
P3181
P356
10.1038/376435A0
P407
P577
1995-08-03T00:00:00Z
P6179
1002096734