The heparin-binding domain of amphiregulin necessitates the precursor pro-region for growth factor secretion
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Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cellsN-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration.Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavageMaternal heparin-binding-EGF deficiency limits pregnancy success in mice.Neisseria gonorrhoeae infection induces altered amphiregulin processing and releaseThe membrane-anchoring domain of epidermal growth factor receptor ligands dictates their ability to operate in juxtacrine modeEpidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturationStructural requirements for the tissue-specific and tissue-general functions of the Caenorhabditis elegans epidermal growth factor LIN-3.Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furinTransautocrine signaling by membrane neuregulins requires cell surface targeting, which is controlled by multiple domainsA variant epidermal growth factor receptor exhibits altered type alpha transforming growth factor binding and transmembrane signalingRemoval of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization.Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells.The kinetics of the hydrogen/deuterium exchange of epidermal growth factor receptor ligands.Myofibroblast keratinocyte growth factor reduces tight junctional integrity and increases claudin-2 levels in polarized Caco-2 cells.Amphiregulin as a novel target for breast cancer therapy.Tetraspanins Function as Regulators of Cellular Signaling.Fractones: extracellular matrix niche controlling stem cell fate and growth factor activity in the brain in health and disease.Fractone-heparan sulphates mediate FGF-2 stimulation of cell proliferation in the adult subventricular zone.Amphiregulin exosomes increase cancer cell invasion.Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells.Pro-sequence-assisted protein folding.The proamphiregulin cytoplasmic domain is required for basolateral sorting, but is not essential for constitutive or stimulus-induced processing in polarized Madin-Darby canine kidney cells.Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form.Expression of epidermal growth factor and its receptor in cirrhotic liver disease.Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin.Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy.Developmental changes of epidermal growth factor-like immunoreactivity in the human fetal brain.
P2860
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P2860
The heparin-binding domain of amphiregulin necessitates the precursor pro-region for growth factor secretion
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
The heparin-binding domain of ...... on for growth factor secretion
@en
The heparin-binding domain of ...... on for growth factor secretion
@nl
type
label
The heparin-binding domain of ...... on for growth factor secretion
@en
The heparin-binding domain of ...... on for growth factor secretion
@nl
prefLabel
The heparin-binding domain of ...... on for growth factor secretion
@en
The heparin-binding domain of ...... on for growth factor secretion
@nl
P2860
P356
P1476
The heparin-binding domain of ...... on for growth factor secretion
@en
P2093
P2860
P304
P356
10.1128/MCB.14.3.1635
P407
P577
1994-03-01T00:00:00Z