NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols.
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Notch signaling: its roles and therapeutic potential in hematological malignanciesThe relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemiaA cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia.The indicative effect of Notch1 expression for the prognosis of T-cell acute lymphocytic leukemia: a systematic review.Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic miceOncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia.Beyond the 2008 World Health Organization classification: the role of the hematopathology laboratory in the diagnosis and management of acute lymphoblastic leukemiaAugmented efficacy with the combination of blockade of the Notch-1 pathway, bortezomib and romidepsin in a murine MT-1 adult T-cell leukemia model.Mutational spectrum of adult T-ALLCharacterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic LeukemiaMutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia.UV-Induced Wnt7a in the Human Skin Microenvironment Specifies the Fate of Neural Crest-Like Cells via Suppression of Notch.Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutationsThe significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia.Impact of PTEN abnormalities on outcome in pediatric patients with T-cell acute lymphoblastic leukemia treated on the MRC UKALL2003 trialMicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid MalignanciesThe NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy.NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia.Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia.The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest.Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutationsMolecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia.p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies.T-cell acute lymphoblastic leukaemia: recent molecular biology findings.The molecular basis of T cell acute lymphoblastic leukemiaLessons from next-generation sequencing analysis in hematological malignancies.Current status and future directions of T-lymphoblastic lymphoma in children and adolescents.Interaction of Ras with p110γ is required for thymic β-selection in the mouse.Pediatric T-cell acute lymphoblastic leukemia.Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cellsFBXW7 regulates glucocorticoid response in T-cell acute lymphoblastic leukaemia by targeting the glucocorticoid receptor for degradation.Prognostic implications of mutations in NOTCH1 and FBXW7 in childhood T-ALL treated according to the NOPHO ALL-1992 and ALL-2000 protocols.Absence of biallelic TCRγ deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia.Genetic mutational profiling analysis of T cell acute lymphoblastic leukemia reveal mutant FBXW7 as a prognostic indicator for inferior survival.The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia.MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia.NOTCH1 mutation, TP53 alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia
P2860
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P2860
NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
NOTCH1 and/or FBXW7 mutations ...... ed on DCOG or COALL protocols.
@en
NOTCH1 and/or FBXW7 mutations ...... ed on DCOG or COALL protocols.
@nl
type
label
NOTCH1 and/or FBXW7 mutations ...... ed on DCOG or COALL protocols.
@en
NOTCH1 and/or FBXW7 mutations ...... ed on DCOG or COALL protocols.
@nl
prefLabel
NOTCH1 and/or FBXW7 mutations ...... ed on DCOG or COALL protocols.
@en
NOTCH1 and/or FBXW7 mutations ...... ed on DCOG or COALL protocols.
@nl
P2093
P2860
P356
P1433
P1476
NOTCH1 and/or FBXW7 mutations ...... ed on DCOG or COALL protocols.
@en
P2093
A J P Veerman
E F Petricoin
E Sonneveld
I Homminga
J G C A M Buijs-Gladdines
J P P Meijerink
L Zuurbier
M Horstmann
M L te Winkel
P2860
P2888
P304
P356
10.1038/LEU.2010.204
P577
2010-09-23T00:00:00Z
P5875
P6179
1015955394