Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335).

Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335).

Item
http://www.wikidata.org/entity/Q42935191
Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335Minimum costs for producing hepatitis C direct-acting antivirals for use in large-scale treatment access programs in developing countries.Identification of novel small molecules as inhibitors of hepatitis C virus by structure-based virtual screening.Current and future therapies for hepatitis C virus infection: from viral proteins to host targets.Faldaprevir (BI 201335) for the treatment of hepatitis C in patients co-infected with HIV.Viral resistance in hepatitis C virus genotype 1-infected patients receiving the NS3 protease inhibitor Faldaprevir (BI 201335) in a phase 1b multiple-rising-dose study.Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure.Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A proteaseMass balance and metabolite profiling of steady-state faldaprevir, a hepatitis C virus NS3/4 protease inhibitor, in healthy male subjects.In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335.Advanced asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by alkylation/cyclization of newly designed axially chiral Ni(II) complex of glycine Schiff base.Hepatitis C virus serine protease: synthesis of radioactive and stable isotope-labeled potent inhibitors.Safety and efficacy of faldaprevir with pegylated interferon alfa-2a and ribavirin in Japanese patients with chronic genotype-1 hepatitis C infection.Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor.Proteases and protease inhibitors in infectious diseases.Biotransformation and mass balance of faldaprevir, a hepatitis C NS3/NS4 protease inhibitor in rats
P2860

Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335).

Item
http://www.wikidata.org/entity/Q42935191
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Discovery of a potent and sele ...... irus NS3 protease (BI 201335).
@en
Discovery of a potent and sele ...... hepatitis C virus NS3 protease
@nl
type
label
Discovery of a potent and sele ...... irus NS3 protease (BI 201335).
@en
Discovery of a potent and sele ...... hepatitis C virus NS3 protease
@nl
prefLabel
Discovery of a potent and sele ...... irus NS3 protease (BI 201335).
@en
Discovery of a potent and sele ...... hepatitis C virus NS3 protease
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Discovery of a potent and sele ...... virus NS3 protease (BI 201335)
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698