Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repair.
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Chronic exposure to zinc chromate induces centrosome amplification and spindle assembly checkpoint bypass in human lung fibroblastsCytogenomics of hexavalent chromium (Cr 6+) exposed cells: a comprehensive reviewInvolvement of free radicals in breast cancerGenetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromiumAssessment of Cr(VI)-induced cytotoxicity and genotoxicity using high content analysisAssessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humansThe effects of chromium(VI) on the thioredoxin system: implications for redox regulationLong-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of MiceXPA impacts formation but not proteasome-sensitive repair of DNA-protein cross-links induced by chromateMonitoring Cr intermediates and reactive oxygen species with fluorescent probes during chromate reduction.Mechanism of DNA-protein cross-linking by chromiumAdverse hematological effects of hexavalent chromium: an overviewZinc chromate induces chromosome instability and DNA double strand breaks in human lung cells.Chromium and genomic stabilityS-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.The intracellular redox stress caused by hexavalent chromium is selective for proteins that have key roles in cell survival and thiol redox control.DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.Chromium(VI) causes interstrand DNA cross-linking in vitro but shows no hypersensitivity in cross-link repair-deficient human cellsChromium in drinking water: sources, metabolism, and cancer risksWRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts.Oral Chromium Exposure and Toxicity.Metabolism of Cr(VI) by ascorbate but not glutathione is a low oxidant-generating process.Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels.Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent ChromiumDifferent ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics.Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolismHexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure.Modulation of histone methylation and MLH1 gene silencing by hexavalent chromiumThe Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage.Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 yearsGeneration of oxidant response to copper and iron nanoparticles and salts: Stimulation by ascorbate.Mechanisms of metal-induced centrosome amplification.Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers.Chromium-induced genotoxicity and interference in human lymphoblastoid cell (TK6) repair processes.Chromium induces chromosomal instability, which is partly due to deregulation of BubR1 and Emi1, two APC/C inhibitors.Comparative study of two evaluation methods for the genotoxic effects of environmental heavy metals on normal cells.Variation in Extracellular Detoxification Is a Link to Different Carcinogenicity among Chromates in Rodent and Human LungsLong-term exposure to hexavalent chromium inhibits expression of tumor suppressor genes in cultured cells and in mice.Prospective role of ascorbic acid (vitamin C) in attenuating hexavalent chromium-induced functional and cellular damage in rat thyroid.A Water-Stable Luminescent ZnII Metal-Organic Framework as Chemosensor for High-Efficiency Detection of CrVI -Anions (Cr2 O72- and CrO42- ) in Aqueous Solution.
P2860
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P2860
Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repair.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Ascorbate acts as a highly pot ...... n G2 phase by mismatch repair.
@en
Ascorbate acts as a highly pot ...... n G2 phase by mismatch repair.
@nl
type
label
Ascorbate acts as a highly pot ...... n G2 phase by mismatch repair.
@en
Ascorbate acts as a highly pot ...... n G2 phase by mismatch repair.
@nl
prefLabel
Ascorbate acts as a highly pot ...... n G2 phase by mismatch repair.
@en
Ascorbate acts as a highly pot ...... n G2 phase by mismatch repair.
@nl
P2093
P2860
P356
P1476
Ascorbate acts as a highly pot ...... n G2 phase by mismatch repair.
@en
P2093
Anatoly Zhitkovich
Ivan Bespalov
Lauren Stoddard
Mindy Reynolds
P2860
P304
P356
10.1093/NAR/GKL1069
P407
P577
2006-12-14T00:00:00Z