The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.
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STIM and Orai1 Variants in Store-Operated Calcium EntryStructural aspects of calcium-release activated calcium channel functionThe STIM1/Orai signaling machineryPathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in ThrombopoiesisSterol hindrance of Orai activationConformational Changes in the Orai1 C-Terminus Evoked by STIM1 BindingSequential Steps of CRAC Channel Activation.STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel.Molecular biophysics of Orai store-operated Ca2+ channels.STIM1L traps and gates Orai1 channels without remodeling the cortical ERStore-operated calcium entry: Mechanisms and modulation.Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating.Cooperative Binding of Stromal Interaction Molecule 1 (STIM1) to the N and C Termini of Calcium Release-activated Calcium Modulator 1 (Orai1).Cholesterol modulates Orai1 channel functionStructural and functional mechanisms of CRAC channel regulation.Molecular mechanisms of STIM/Orai communication.CRAC channel gating and its modulation by STIM1 and 2-aminoethoxydiphenyl borate.Molecular mechanisms underlying inhibition of STIM1-Orai1-mediated Ca2+ entry induced by 2-aminoethoxydiphenyl borate.The STIM-Orai coupling interface and gating of the Orai1 channel.Pore opening mechanism of CRAC channels.The STIM1-binding site nexus remotely controls Orai1 channel gating.STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.The Orai1 Store-operated Calcium Channel Functions as a Hexamer.Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N-terminus.Communication between N-terminus and Loop2 tunes Orai activation.Ca2+ and lipid signals hold hands at endoplasmic reticulum-plasma membrane contact sites.Cardiovascular and Hemostatic Disorders: SOCE and Ca2+ Handling in Platelet Dysfunction.The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry.The STIM-Orai Pathway: The Interactions Between STIM and Orai.The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel.The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex.Store-Operated Calcium Channels.
P2860
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P2860
The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
The extended transmembrane Ora ...... for Orai1 activation by STIM1.
@en
The extended transmembrane Orai1 N-terminal
@nl
type
label
The extended transmembrane Ora ...... for Orai1 activation by STIM1.
@en
The extended transmembrane Orai1 N-terminal
@nl
prefLabel
The extended transmembrane Ora ...... for Orai1 activation by STIM1.
@en
The extended transmembrane Orai1 N-terminal
@nl
P2093
P2860
P356
P1476
The extended transmembrane Ora ...... for Orai1 activation by STIM1.
@en
P2093
Hermann J Gruber
Isaac Jardin
Isabella Derler
Klaus Groschner
Marc Fahrner
Martin Muik
Peter Plenk
P2860
P304
29025-29034
P356
10.1074/JBC.M113.501510
P407
P577
2013-08-13T00:00:00Z