about
Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entrySTIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entryLpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel.Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.Assembly domains in TRP channels.A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 ChannelsIncreased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutantThe STIM/Orai coupling machinery.Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutantA calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription.Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.Recent progress on STIM1 domains controlling Orai activation.Cholesterol modulates Orai1 channel functionGating and permeation of Orai channels.Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation.CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells.Crosstalk between voltage-independent Ca2+ channels and L-type Ca2+ channels in A7r5 vascular smooth muscle cells at elevated intracellular pH: evidence for functional coupling between L-type Ca2+ channels and a 2-APB-sensitive cation channel.Store depletion-activated CaT1 currents in rat basophilic leukemia mast cells are inhibited by 2-aminoethoxydiphenyl borate. Evidence for a regulatory component that controls activation of both CaT1 and CRAC (Ca(2+) release-activated Ca(2+) channel)Mrs2p forms a high conductance Mg2+ selective channel in mitochondria.Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasiaCellular interfaces with hydrogen-bonded organic semiconductor hierarchical nanocrystals.Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx.A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.Communication between N-terminus and Loop2 tunes Orai activation.Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.The STIM-Orai Pathway: The Interactions Between STIM and Orai.An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.STIM1 and Orai1 regulate Ca microdomains for activation of transcriptionCRAC inhibitors: identification and potentialOptoelectronic control of single cells using organic photocapacitorsMechanistic insights into the Orai channel by molecular dynamics simulationsSequential activation of STIM1 links Ca2+ with luminal domain unfoldingTRPC-mediated Ca2+ signaling and control of cellular functionsProtein–Protein Interactions in TRPC Channel ComplexesStudies of Structure-Function and Subunit Composition of Orai/STIM Channel
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Rainer Schindl
@ast
Rainer Schindl
@en
Rainer Schindl
@es
Rainer Schindl
@nl
Rainer Schindl
@sl
type
label
Rainer Schindl
@ast
Rainer Schindl
@en
Rainer Schindl
@es
Rainer Schindl
@nl
Rainer Schindl
@sl
prefLabel
Rainer Schindl
@ast
Rainer Schindl
@en
Rainer Schindl
@es
Rainer Schindl
@nl
Rainer Schindl
@sl
P1053
E-3959-2013
P106
P21
P31
P3829
P496
0000-0003-0896-8887