Internalization and down-regulation of the prostacyclin receptor in human platelets.
about
Regulation of prostacyclin and prostaglandin E(2) receptor mediated responses in adult rat dorsal root ganglion cells, in vitroProtein kinases A and C regulate receptor-mediated increases in cAMP in rabbit erythrocytes.The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.Internalization and sequestration of the human prostacyclin receptor.Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling.Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6.Prostacyclin receptor regulation--from transcription to trafficking.Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively.Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.Agonist-dependent internalization and trafficking of the human prostacyclin receptor: a direct role for Rab5a GTPasePalmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation.Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase.Platelet glycolytic flux increases stimulated by ultraviolet-induced stress is not the direct cause of platelet morphology and activation changes: possible implications for the role of glucose in platelet storage.Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase.Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c.
P2860
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P2860
Internalization and down-regulation of the prostacyclin receptor in human platelets.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Internalization and down-regulation of the prostacyclin receptor in human platelets.
@en
Internalization and down-regulation of the prostacyclin receptor in human platelets.
@nl
type
label
Internalization and down-regulation of the prostacyclin receptor in human platelets.
@en
Internalization and down-regulation of the prostacyclin receptor in human platelets.
@nl
prefLabel
Internalization and down-regulation of the prostacyclin receptor in human platelets.
@en
Internalization and down-regulation of the prostacyclin receptor in human platelets.
@nl
P2093
P2860
P356
P1433
P1476
Internalization and down-regulation of the prostacyclin receptor in human platelets.
@en
P2093
P2860
P356
10.1042/BJ3250071
P407
P478
325 ( Pt 1)
P577
1997-07-01T00:00:00Z