G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium.
about
Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activityPharmacological treatment options for mast cell activation diseaseAnti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapsesLabel-free phenotypic profiling identified D-luciferin as a GPR35 agonistIdentification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screenIdentification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.Systemic mastocytosis with KIT V560G mutation presenting as recurrent episodes of vascular collapse: response to disodium cromoglycate and disease outcomeHigh-throughput identification and characterization of novel, species-selective GPR35 agonists.The therapeutic potential of orphan GPCRs, GPR35 and GPR55.Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice.Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction.Stratified approaches to the treatment of asthma.G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35Crucial positively charged residues for ligand activation of the GPR35 receptor.Respiratory allergies: a general overview of remedies, delivery systems, and the need to progressThe actual role of sodium cromoglycate in the treatment of asthma--a critical review.Combining label-free cell phenotypic profiling with computational approaches for novel drug discovery.G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease.Mast cells in asthma--state of the art.Mast Cells and Anaphylaxis.The Hidden Side of Disodium Cromolyn: from Mast Cell Stabilizer to an Angiogenic Factor and Antitumor Agent.Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells.Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists.Mast cells mediate early neutrophil recruitment and exhibit anti-inflammatory properties via the formyl peptide receptor 2/lipoxin A4 receptor.Chemical genomic analysis of GPR35 signaling.Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors.Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists.Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues.Antagonists of GPR35 display high species ortholog selectivity and varying modes of action.Systemic mast cell degranulation increases mortality during polymicrobial septic peritonitis in mice.Multiple tyrosine metabolites are GPR35 agonists.Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.GPR35 is a target of the loop diuretic drugs bumetanide and furosemide.Oral and topical sodium cromoglicate in the treatment of diffuse cutaneous mastocytosis in an infant.The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists.Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism.The Anti-allergic Cromones: Past, Present, and Future.GPR35 mediates lodoxamide-induced migration inhibitory response but not CXCL17-induced migration stimulatory response in THP-1 cells; is GPR35 a receptor for CXCL17?
P2860
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P2860
G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
G-protein-coupled receptor 35 ...... isodium and nedocromil sodium.
@en
G-protein-coupled receptor 35 ...... isodium and nedocromil sodium.
@nl
type
label
G-protein-coupled receptor 35 ...... isodium and nedocromil sodium.
@en
G-protein-coupled receptor 35 ...... isodium and nedocromil sodium.
@nl
prefLabel
G-protein-coupled receptor 35 ...... isodium and nedocromil sodium.
@en
G-protein-coupled receptor 35 ...... isodium and nedocromil sodium.
@nl
P2093
P356
P1433
P1476
G-protein-coupled receptor 35 ...... isodium and nedocromil sodium.
@en
P2093
Christiaan Saris
Jeff D Reagan
Jenny Ying-Lin Lu
John Whoriskey
Shamin Summer
Yuhua Yang
P356
10.1159/000314164
P577
2010-06-19T00:00:00Z