Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.
about
Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitorsChutes and ladders in hepatitis C nucleoside drug developmentEfficiency of incorporation and chain termination determines the inhibition potency of 2'-modified nucleotide analogs against hepatitis C virus polymeraseSynthesis and anti-HIV activity of 2'-deoxy-2'-fluoro-4'-C-ethynyl nucleoside analogs.Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species.Iodine monochloride facilitated deglycosylation, anomerization, and isomerization of 3-substituted thymidine analogues.Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents.Potential use of antiviral agents in polio eradication.Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection.Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.Highlights in antiviral drug research: antivirals at the horizon.A review of methods to synthesise 4'-substituted nucleosides.4'-Azidocytidine (R1479) inhibits henipaviruses and other paramyxoviruses with high potency.Natural prevalence of hepatitis C virus (HCV) variants resistant to protease and polymerase inhibitors in patients infected with HCV genotype 1 in Tunisia.Synthesis of novel 4'α-trifluoromethyl-2'β-C-methyl-carbodine analogs as anti-hepatitis C virus agents.Synthesis and anti-HCV evaluation of 4'(alpha)-ethyl and 2'(beta)-methyl-carbodine analogues.Antiviral screening identifies adenosine analogs targeting the endogenous dsRNA Leishmania RNA virus 1 (LRV1) pathogenicity factor.2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.Synthesis and antiviral evaluation of 4'-C-azidomethyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides.Chemical stability of 4'-azidocytidine and its prodrug balapiravir.Structural study of 1-(2', 3'-O-isopropylidene-(α-d-allo and -β-l-talofuranosyluron)-5'-cyanohydrin)uracil stereoisomers by NMR spectroscopy and theoretical methods.Comparison of the diastereoisomeric excess of uridine, inosine and adenosine cyanohydrins determined by HPLC-DAD and 1H NMR.Susceptibility of paramyxoviruses and filoviruses to inhibition by 2'-monofluoro- and 2'-difluoro-4'-azidocytidine analogs.New pyrosequencing method to analyze the function of the Klenow fragment (EXO-) for unnatural nucleic acids: pyrophosphorolysis and incorporation efficiency.
P2860
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P2860
Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Design, synthesis, and antivir ...... ation: the discovery of R1479.
@en
Design, synthesis, and antivir ...... ation: the discovery of R1479.
@nl
type
label
Design, synthesis, and antivir ...... ation: the discovery of R1479.
@en
Design, synthesis, and antivir ...... ation: the discovery of R1479.
@nl
prefLabel
Design, synthesis, and antivir ...... ation: the discovery of R1479.
@en
Design, synthesis, and antivir ...... ation: the discovery of R1479.
@nl
P2093
P1476
Design, synthesis, and antivir ...... ation: the discovery of R1479.
@en
P2093
Arkadius Pichota
Carl Laxton
Caroline Granycome
Christopher J Hobbs
David B Smith
David Vesey
Graham Maile
Isabel Najera
John H Merrett
P304
P356
10.1016/J.BMCL.2007.02.004
P407
P577
2007-02-04T00:00:00Z