The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate.
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Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activityStructures of hepatitis C virus nonstructural proteins required for replicase assembly and functionThe Two-component NS2B-NS3 Proteinase Represses DNA Unwinding Activity of the West Nile Virus NS3 HelicaseHepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 HelicaseThe NS4A Protein of Hepatitis C Virus Promotes RNA-Coupled ATP Hydrolysis by the NS3 HelicaseHelicase inhibitors as specifically targeted antiviral therapy for hepatitis CHepatitis C Virus NS2 Protein Contributes to Virus Particle Assembly via Opposing Epistatic Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme ComplexesThree conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.Mechanism and Specificity of a Symmetrical Benzimidazolephenylcarboxamide Helicase InhibitorInterplay between NS3 protease and human La protein regulates translation-replication switch of Hepatitis C virusVisualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCVDiscovery of an allosteric mechanism for the regulation of HCV NS3 protein functionA macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length targetInhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon spNatural HCV variants with increased replicative fitness due to NS3 helicase mutations in the C-terminal helix α18X-ray structure of the pestivirus NS3 helicase and its conformation in solution.The NPH-II helicase displays efficient DNA x RNA helicase activity and a pronounced purine sequence biasThe protease domain increases the translocation stepping efficiency of the hepatitis C virus NS3-4A helicase.Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral targetPreparation of HCV NS3 and NS5B proteins to support small-molecule drug discovery.Double-stranded RNA-dependent ATPase DRH-3: insight into its role in RNAsilencing in Caenorhabditis elegansRNA helicases: emerging roles in viral replication and the host innate response.Hepatitis C Virus NS3/4A Protease Inhibitors: A Light at the End of the Tunnel.Novel ATP-independent RNA annealing activity of the dengue virus NS3 helicaseThe linker region of NS3 plays a critical role in the replication and infectivity of hepatitis C virus.Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assaysIn silico identification and evaluation of leads for the simultaneous inhibition of protease and helicase activities of HCV NS3/4A protease using complex based pharmacophore mapping and virtual screening.Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitorKetoamide resistance and hepatitis C virus fitness in val55 variants of the NS3 serine protease.HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human HepatocytesSingle-molecule imaging reveals the translocation and DNA looping dynamics of hepatitis C virus NS3 helicase.RNA binding by the NS3 protease of the hepatitis C virusResistance studies of a dithiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems.Minimum requirements for bluetongue virus primary replication in vivo.Identification and analysis of inhibitors targeting the hepatitis C virus NS3 helicaseFluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation.Melting of Duplex DNA in the Absence of ATP by the NS3 Helicase Domain through Specific Interaction with a Single-Strand/Double-Strand JunctionCellular and molecular biology of HCV infection and hepatitis.Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.Parts, assembly and operation of the RIG-I family of motors.
P2860
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P2860
The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
The serine protease domain of ...... the binding of RNA substrate.
@en
The serine protease domain of ...... the binding of RNA substrate.
@nl
type
label
The serine protease domain of ...... the binding of RNA substrate.
@en
The serine protease domain of ...... the binding of RNA substrate.
@nl
prefLabel
The serine protease domain of ...... the binding of RNA substrate.
@en
The serine protease domain of ...... the binding of RNA substrate.
@nl
P2093
P2860
P356
P1476
The serine protease domain of ...... the binding of RNA substrate.
@en
P2093
Anna Marie Pyle
Rudolf K F Beran
Victor Serebrov
P2860
P304
34913-34920
P356
10.1074/JBC.M707165200
P407
P577
2007-10-05T00:00:00Z