Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population. - Wikidata - wikimedia - TriplyDB

Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.

Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.

http://www.wikidata.org/entity/Q43109279

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Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein Common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility The genetics of hyperuricaemia and gout Renal transport of uric acid: evolving concepts and uncertainties The pharmacological impact of ATP-binding cassette drug transporters on vemurafenib-based therapy Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea.ABCG2: the molecular mechanisms of urate secretion and gout Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study Expression levels of the ABCG2 multidrug transporter in human erythrocytes correspond to pharmacologically relevant genetic variations Regulation of the Axillary Osmidrosis-Associated ABCC11 Protein Stability by N-Linked Glycosylation: Effect of Glucose Condition Jump into a New Fold-A Homology Based Model for the ABCG2/BCRP Multidrug Transporter The Effect of Albumin on MRP2 and BCRP in the Vesicular Transport Assay Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2 Crystal arthritides - gout and calcium pyrophosphate arthritis : Part 1: Epidemiology and pathophysiology.Allopurinol: insights from studies of dose-response relationships.Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approaches Metabolic syndrome, alcohol consumption and genetic factors are associated with serum uric acid concentration Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations: the PAGE Study.Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk.The genetics of gout: towards personalised medicine?Functional polymorphisms of the ABCG2 gene are associated with gout disease in the Chinese Han male population Cichorium intybus L. promotes intestinal uric acid excretion by modulating ABCG2 in experimental hyperuricemia Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population.Serum uric acid distribution according to SLC22A12 W258X genotype in a cross-sectional study of a general Japanese population.Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations.Complex analysis of urate transporters SLC2A9, SLC22A12 and functional characterization of non-synonymous allelic variants of GLUT9 in the Czech population: no evidence of effect on hyperuricemia and gout.Gout: a review of nonmodifiable and modifiable risk factors.Decreased extra-renal urate excretion is a common cause of hyperuricemia Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus.Common variant of ALPK1 is not associated with gout: a replication study.New and improved strategies for the treatment of gout The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population.ASSOCIATIONS BETWEEN BODY MASS INDEX AND SERUM URIC ACID LEVELS IN A JAPANESE POPULATION WERE SIGNIFICANTLY MODIFIED BY LRP2 rs2544390.No association between MTHFR C677T and serum uric acid levels among Japanese with ABCG2 126QQ and SLC22A12 258WW.ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout.Gout, genetics and ABC transporters.Pharmacogenomics of human ABC transporter ABCC11 (MRP8): potential risk of breast cancer and chemotherapy failure Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones.

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P2860

Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.

http://www.wikidata.org/entity/Q43109279

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Hideharu Domoto

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Hiroki Inoue

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Hiroshi Suzuki

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Hirotaka Matsuo

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Junichiro Nishiyama

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Kazuko Nishio

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Kimiyoshi Ichida

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P2860

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations

Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

Urate oxidase: primary structure and evolutionary implications

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large family

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