about
Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomesNovel repressor regulates insulin sensitivity through interaction with Foxo1HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cellsInsulin receptor substrate-3 functions as transcriptional activator in the nucleusConstitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblastsParaquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.Nexilin, a cardiomyopathy-associated F-actin binding protein, binds and regulates IRS1 signaling in skeletal muscle cells.Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation.KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells.The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation.Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression.Growth hormone (GH) or insulin-like growth factor (IGF)-I represses 11beta-hydroxysteroid dehydrogenase type 1 (HSD1) mRNA expression in 3T3-L1 cells and its activity in their homogenates.Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity.Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans.Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin beta.Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic ratsPKCα suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Fumihiko Hakuno
@ast
Fumihiko Hakuno
@en
Fumihiko Hakuno
@es
Fumihiko Hakuno
@nl
Fumihiko Hakuno
@sl
type
label
Fumihiko Hakuno
@ast
Fumihiko Hakuno
@en
Fumihiko Hakuno
@es
Fumihiko Hakuno
@nl
Fumihiko Hakuno
@sl
prefLabel
Fumihiko Hakuno
@ast
Fumihiko Hakuno
@en
Fumihiko Hakuno
@es
Fumihiko Hakuno
@nl
Fumihiko Hakuno
@sl
P106
P21
P31
P496
0000-0002-4447-6225
P569
2000-01-01T00:00:00Z