Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q). - Wikidata - wikimedia - TriplyDB

Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

http://www.wikidata.org/entity/Q43143386

about

Cell-surface receptors transactivation mediated by g protein-coupled receptors The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis Integrins as Therapeutic Targets for Respiratory Diseases Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis.Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin-p42/44MAPK-GEF-H1 complex.Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription.Requirement of Osteopontin in the migration and protection against Taxol-induced apoptosis via the ATX-LPA axis in SGC7901 cells.Pathogenesis of idiopathic pulmonary fibrosis A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model.TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis.Aiming drug discovery at lysophosphatidic acid targets.Transforming growth factor-beta promotes rhinovirus replication in bronchial epithelial cells by suppressing the innate immune response.HMGB1 accelerates alveolar epithelial repair via an IL-1β- and αvβ6 integrin-dependent activation of TGF-β1 Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation.Novel therapeutic approaches for pulmonary fibrosis.Cytoprotective-selective activated protein C attenuates Pseudomonas aeruginosa-induced lung injury in mice.Cloning and characterization of the human integrin β6 gene promoter Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma Pathogenesis of Systemic Sclerosis.LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage.Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.Cigarette Smoke Enhances the Expression of Profibrotic Molecules in Alveolar Epithelial Cells.Fibrosis in systemic sclerosis: common and unique pathobiology.Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma.Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling.Role of Krev Interaction Trapped-1 in Prostacyclin-Induced Protection against Lung Vascular Permeability Induced by Excessive Mechanical Forces and Thrombin Receptor Activating Peptide 6.Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells.LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation.Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma.The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation.Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis.Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice.Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities.Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing.Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy.The Role of TGF-β Receptors in Fibrosis.Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors.New renal drug development to face chronic renal disease.

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Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

http://www.wikidata.org/entity/Q43143386

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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name

Lysophosphatidic acid induces ...... nd the small G protein G alpha

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Lysophosphatidic acid induces ...... he small G protein G alpha(q).

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type

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Lysophosphatidic acid induces ...... nd the small G protein G alpha

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Lysophosphatidic acid induces ...... he small G protein G alpha(q).

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Lysophosphatidic acid induces ...... nd the small G protein G alpha

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AJPATH.2009.080160

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The American Journal of Pathology

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Lysophosphatidic acid induces ...... he small G protein G alpha(q).

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Alan J Knox

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Dean Sheppard

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Joanne Porte

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Ming Yan Xu

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Robin J McAnulty

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Shelia M Violette

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P2860

Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis

Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta

G protein pathways.

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA

Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement

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1264-1279

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23791755

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