Does the long plasma half-life of 4beta-hydroxycholesterol impact its utility as a cytochrome P450 3A (CYP3A) metric?
about
Validation of 4β-hydroxycholesterol and evaluation of other endogenous biomarkers for the assessment of CYP3A activity in healthy subjects4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.Quantitation of P450 3A4 endogenous biomarker - 4β-hydroxycholesterol - in human plasma using LC/ESI-MS/MS.The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity.4β-hydroxycholesterol as an endogenous CYP3A marker in cancer patients treated with taxanes.UHPLC-MS/MS bioanalysis of urinary DHEA, cortisone and their hydroxylated metabolites as potential biomarkers for CYP3A-mediated drug-drug interactions.Perspective: 4β-hydroxycholesterol as an emerging endogenous biomarker of hepatic CYP3A.The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation.An Exposure-Response Modeling Approach to Examine the Relationship Between Potency of CYP3A Inducer and Plasma 4β-Hydroxycholesterol in Healthy Subjects.Evaluation of 4β-Hydroxycholesterol as a Clinical Biomarker of CYP3A4 Drug Interactions Using a Bayesian Mechanism-Based Pharmacometric Model.Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance.Coadministration of Rifampin Significantly Reduces Odanacatib Concentrations in Healthy Subjects.Cytochrome P450 3A activity in mothers and their neonates as determined by plasma 4β-hydroxycholesterol.
P2860
Q34570949-A51704FC-D152-4D46-B7AF-91EADCC74546Q34580565-96F27B83-650E-4873-ADFC-B0B859D89721Q35174116-C6A3F34F-74D7-4BC8-B94F-31CF0595C455Q36072482-29057466-BD40-4887-B79F-C25D02C227E6Q36072512-A3748F3A-D978-4AC7-9970-C30D2F1A6E6EQ38794444-2C916EC4-40E7-496A-AED0-8F40EF43E328Q38813488-2453CD8E-81D2-4C49-A738-6ED5E8D2D508Q38986439-07DF8377-F5A2-4412-BC53-7F461AB99DECQ39800984-1C8342A7-0AAD-45CD-B32E-CB8F51F36FC7Q41556479-5A91AB2F-2169-4F75-BF3E-CF5522C2B1FBQ47400761-FF5D8B28-C61C-40C6-A82E-4668B73E07C5Q51694212-D6B92F5D-1F54-491A-91CA-D6FB9586604EQ51732246-80FCA65A-3138-4C9C-A490-290B226DCAF7
P2860
Does the long plasma half-life of 4beta-hydroxycholesterol impact its utility as a cytochrome P450 3A (CYP3A) metric?
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Does the long plasma half-life ...... chrome P450 3A (CYP3A) metric?
@en
Does the long plasma half-life ...... tility as a cytochrome P450 3A
@nl
type
label
Does the long plasma half-life ...... chrome P450 3A (CYP3A) metric?
@en
Does the long plasma half-life ...... tility as a cytochrome P450 3A
@nl
prefLabel
Does the long plasma half-life ...... chrome P450 3A (CYP3A) metric?
@en
Does the long plasma half-life ...... tility as a cytochrome P450 3A
@nl
P2860
P356
P1476
Does the long plasma half-life ...... chrome P450 3A (CYP3A) metric?
@en
P2093
A David Rodrigues
Zheng Yang
P2860
P304
P356
10.1177/0091270009360041
P577
2010-03-02T00:00:00Z